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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Osteoconductivity of modified fluorcanasite glass-ceramics for bone tissue augmentation and repair

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Author(s):
Bandyopadhyay-Ghosh, S. [1, 2] ; Faria, P. E. P. [3] ; Johnson, A. [1] ; Felipucci, D. N. B. [4] ; Reaney, I. M. [2] ; Salata, L. A. [5] ; Brook, I. M. [1] ; Hatton, P. V. [1]
Total Authors: 8
Affiliation:
[1] Univ Sheffield, Ctr Biomat & Tissue Engn, Sch Clin Dent, Sheffield S10 2TA, S Yorkshire - England
[2] Univ Sheffield, Dept Mat Engn, Sheffield S1 3JD, S Yorkshire - England
[3] Univ State Sao Paulo, Dept Oral & Maxillofacial Surg, Fac Dent Aracatuba, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Prosthodont, Fac Dent Ribeirao Preto, Sao Paulo - Brazil
[5] Univ Sao Paulo, Dept Oral & Maxillofacial Surg, Fac Dent Ribeirao Preto, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Journal of Biomedical Materials Research Part A; v. 94A, n. 3, p. 760-768, SEP 1 2010.
Web of Science Citations: 11
Abstract

Modified fluorcanasite glasses were fabricated by either altering the molar ratios of Na(2)O and CaO or by adding P(2)O(5) to the parent stoichiometric glass compositions. Glasses were converted to glass-ceramics by a controlled two-stage heat treatment process. Rods (2 mm x 4 mm) were produced using the conventional lost-wax casting technique. Osteoconductive 45S5 bioglass was used as a reference material. Biocompatibility and osteoconductivity were investigated by implantation into healing defects (2 mm) in the midshaft of rabbit femora. Tissue response was investigated using conventional histology and scanning electron microscopy. Histological and histomorphometric evaluation of specimens after 12 weeks implantation showed significantly more bone contact with the surface of 45S5 bioglass implants when compared with other test materials. When the bone contact for each material was compared between experimental time points, the Glass-Ceramic 2 (CaO rich) group showed significant difference (p = 0.027) at 4 weeks, but no direct contact at 12 weeks. Histology and backscattered electron photomicrographs showed that modified fluorcanasite glass-ceramic implants had greater osteoconductivity than the parent stoichiometric composition. Of the new materials, fluorcanasite glass-ceramic implants modified by the addition of P(2)O(5) showed the greatest stimulation of new mineralized bone tissue formation adjacent to the implants after 4 and 12 weeks implantation. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 94A: 760-768, 2010 (AU)