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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cytogenetical damage in exfoliated oral mucosa cells in elderly people suffering denture stomatitis

Full text
Author(s):
Matsumoto, Mariza A. [1] ; Castanho, Juliane [1] ; Kawakami, Roberto Y. [1] ; Ribeiro, Daniel A. [2]
Total Authors: 4
Affiliation:
[1] Univ Cattolica Sacro Cuore, Dept Dent Clin, USC, Bauru, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Biociencias, UNIFESP, BR-11060001 Santos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: GERODONTOLOGY; v. 27, n. 3, p. 183-188, SEP 2010.
Web of Science Citations: 2
Abstract

Objectives: The aim of this study was to evaluate comparatively the DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated oral mucosa cells from chronic denture stomatitis patients and healthy controls. Background: Over the course of ageing, individuals may develop many diseases such as denture stomatitis. Material and methods: A total of 23 chronic denture stomatitis patients and 23 controls presenting good oral conditions were included in this study. Individuals had epithelial cells mechanically exfoliated, placed in fixative and placed on clean slides, which were checked for nuclear phenotypes. Results: The results indicated no statistically significant differences (p > 0.05) of micronucleated oral mucosa cells from chronic denture stomatitis patients when compared to healthy controls. Nevertheless, chronic denture stomatitis was able to increase other nuclear alterations closely related to cytotoxicity such as karyorrhexis, pyknosis and karyolysis as depicted by significant differences (p < 0.05) between groups. No interaction was observed between smoking and chronic denture stomatitis. Conclusion: In summary, these data indicated that chronic denture stomatitis was able to induce cytotoxic effects as assessed by a micronucleus test. (AU)

FAPESP's process: 07/01228-4 - Medium-term oral carcinogenesis assay induced by 4-nitroquinoline 1-oxide in rats: putative biomarkers involved into its pathogenesis
Grantee:Daniel Araki Ribeiro
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 07/00345-7 - DNA damage induced by metal ions from orthodontic therapy: in vivo and in vitro analyses
Grantee:Daniel Araki Ribeiro
Support Opportunities: Regular Research Grants