Association of-308G/A polymorphism in the tumor necrosis factor-alpha gene promoter with susceptibility to development of hantavirus cardiopulmonary syndrome in the Ribeiro Preto region, Brazil

Author(s)

Borges, Alessandra Abel ^{[1, 2]} ; Donadi, Eduardo Antonio ^[3] ; Campos, Gelse Mazzoni ^[1] ; Moreli, Marcos Lazaro ^[1] ; Moro de Sousa, Ricardo Luiz ^{[1, 4]} ; Saggioro, Fabiano Pinto ^[5] ; de Figueiredo, Glauciane Garcia ^[1] ; Badra, Soraya Jabur ^[1] ; Saloum Deghaide, Neifi Hassan ^[3] ; Moraes Figueiredo, Luiz Tadeu ^[1]

Affiliation

^[1] Univ Sao Paulo, Virol Res Ctr, Sch Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Fed Alagoas, Virol & Immunol Res Lab, Maceio - Brazil

^[3] Univ Hosp Ribeirao Preto, Mol Immunol Lab, Ribeirao Preto - Brazil

^[4] Univ Sao Paulo, Dept Basic Sci, Sch Zootechny & Food Engn, Pirassununga - Brazil

^[5] Univ Sao Paulo, Dept Pathol, Sch Med Ribeirao Preto, Death Verificat Serv CEMEL, BR-14049900 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: ARCHIVES OF VIROLOGY; v. 155, n. 6, p. 971-975, JUN 2010.
• Web of Science Citations: 17

Abstract

Activation of the immune response in hantavirus cardiopulmonary syndrome (HCPS) leads to a high TNF production, probably contributing to the disease. The polymorphic TNF2 allele (TNF -308G/A) has been associated with increased cytokine production. We investigated the association of the TNF2 allele with the outcome of hantavirus infection in Brazilian patients. A total of 122 hantavirus-exposed individuals (26 presenting HCPS and 96 only hantavirus seroconversion) were studied. The TNF2 allele was more frequently found in HCPS patients than in individuals with positive serology for hantavirus but without a history of HCPS illness, suggesting that the TNF2 allele could represent a risk factor for developing HCPS. (AU)