| Grant number: |
08/06411-4
|
| Support type: | Scholarships in Brazil - Master |
| Effective date (Start): |
March 01, 2009
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| Effective date (End): |
July 31, 2010
|
| Field of knowledge: | Biological Sciences
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Microbiology |
|
| Principal Investigator: | Luiz Tadeu Moraes Figueiredo |
| Grantee: | Gilberto Sabino dos Santos Junior |
|
| Home Institution: |
Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
|
|
Abstract
The genus Hantavirus, family Bunyaviridae, includes rodent-borne viruses that represent emerging threats to human health. The main route for virus transmission is respiratory via small particle aerosols from rodent excreta and saliva. Hantavirus are associated to rodent hosts of the family Muridae included in 3 sub families, Murinae and Arvicolinae distributed in the Paleartic Region (Europa, Asia, China) causing hemorrhagic fever with renal syndrome (HFRS) and subfamily Sigmodontinae in North, Central and South America responsible for hantavirus cardiopulmonary syndrome (HCPS), besides, an Arvicolinae genus (Microtus) has been found infected with Hantavirus in North America. In Brazil, since 1993 to nowadays, more than 900 cases of HCPS were reported, with a 40% lethality rate. The majority of the cases occurred in Southern and Southeastern states. In Ribeirão Preto occurred about 6% of the Brazilian cases of HCPS. The high number of HCPS cases indicates that this region is suitable for studying the epidemiology of Hantavirus infections. It is known that the knowledge on the rodent population related to Hantavirus, including their dynamics and ecology is essential for better understanding the epidemiology of HCPS. Thus, we propose here to study the dynamics of populations of these rodents in Ribeirão Preto region. We also intend to detect Hantavirus infection in rodents by serology (ELISA), nested RT-PCR and viral isolation in a BSL-3 facility. There is no Hantavirus isolated in Brazil and we recognize that to have these isolates is important for studies on virus morphology, genome and virulence. Finally, we also intend to determine Hantavirus load in clinical samples by real time PCR.
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Scientific publications
(6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA, WILLIAM MARCIEL;
FUMAGALLI, MARCILIO JORGE;
SABINO-SANTOS, JR., GILBERTO;
MOTTA MAIA, FELIPE GONCALVES;
MODHA, SEJAL;
TEIXEIRA NUNES, MARCIO ROBERTO;
MURCIA, PABLO RAMIRO;
MORAES FIGUEIREDO, LUIZ TADEU.
A Novel Hepacivirus in Wild Rodents from South America.
Viruses-Basel,
v. 11,
n. 3
MAR 24 2019.
Web of Science Citations: 0.
MOTTA MAIA, FELIPE GONCALVES;
DE SOUZA, WILLIAM MARCIEL;
SABINO-SANTOS, JR., GILBERTO;
FUMAGALLI, MARCILIO JORGE;
MODHA, SEJAL;
MURCIA, PABLO RAMIRO;
MORAES FIGUEIREDO, LUIZ TADEU.
A novel polyomavirus in sigmodontine rodents from So Paulo State, Brazil.
ARCHIVES OF VIROLOGY,
v. 163,
n. 10,
p. 2913-2915,
OCT 2018.
Web of Science Citations: 0.
DE SOUZA, WILLIAM MARCIEL;
ROMEIRO, MARILIA FARIGNOLI;
SABINO-SANTOS, JR., GILBERTO;
MOTTA MAIA, FELIPE GONCALVES;
FUMAGALLI, MARCILIO JORGE;
MODHA, SEJAL;
TEIXEIRA NUNES, MARCIO ROBERTO;
MURCIA, PABLO RAMIRO;
MORAES FIGUEIREDO, LUIZ TADEU.
Novel orthohepeviruses in wild rodents from Sao Paulo State, Brazil.
VIROLOGY,
v. 519,
p. 12-16,
JUN 2018.
Web of Science Citations: 6.
DE SOUZA, WILLIAM MARCIEL;
DENNIS, TRISTAN;
FUMAGALLI, MARCILIO JORGE;
ARAUJO, JANSEN;
SABINO-SANTOS, JR., GILBERTO;
MOTTA MAIA, FELIPE GONCALVES;
ACRANI, GUSTAVO OLSZANSKI;
TORRES CARRASCO, ADRIANO DE OLIVEIRA;
ROMEIRO, MARILIA FARIGNOLI;
MODHA, SEJAL;
VIEIRA, LUIZ CARLOS;
OMETTO, TATIANA;
QUEIROZ, LUZIA HELENA;
DURIGON, EDISON LUIZ;
TEIXEIRA NUNES, MIRCIO ROBERTO;
MORAES FIGUEIREDO, LUIZ TADEU;
GIFFORD, ROBERT JAMES.
Novel Parvoviruses from Wild and Domestic Animals in Brazil Provide New Insights into Parvovirus Distribution and Diversity.
Viruses-Basel,
v. 10,
n. 4
APR 2018.
Web of Science Citations: 4.
DE SOUZA, WILLIAM MARCIEL;
FUMAGALLI, MARCILIO JORGE;
DE ARAUJO, JANSEN;
SABINO-SANTOS, JR., GILBERTO;
MOTTA MAIA, FELIPE GONSALVES;
ROMEIRO, MARILIA FARIGNOLI;
MODHA, SEJAL;
NARDI, MARCELLO SCHIAVO;
QUEIROZ, LUZIA HELENA;
DURIGON, EDISON LUIZ;
TEIXEIRA NUNES, MARCIO ROBERTO;
MURCIA, PABLO RAMIRO;
MORAES FIGUEIREDO, LUIZ TADEU.
Discovery of novel anelloviruses in small mammals expands the host range and diversity of the Anelloviridae.
VIROLOGY,
v. 514,
p. 9-17,
JAN 15 2018.
Web of Science Citations: 7.
SABINO-SANTOS, JR., GILBERTO;
MAIA, FELIPE G. M.;
JONSSON, COLLEEN B.;
GOODIN, DOUGLAS G.;
SALAZAR-BRAVO, JORGE;
FIGUEIREDO, LUIZ TADEU M.
Serologic Evidence of Mammarenaviruses among Wild Rodents in Brazil.
JOURNAL OF WILDLIFE DISEASES,
v. 52,
n. 3,
p. 766-769,
JUL 2016.
Web of Science Citations: 2.