The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description

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Hoexter, Marcelo Queiroz ^{[1, 2, 3]} ; Shavitt, Roseli Gedanke ^{[1, 2]} ; D'Alcante, Carina Chaubet ^{[1, 2]} ; Cecconi, Janaina Philippi ^{[1, 2]} ; Diniz, Juliana Belo ^{[1, 2]} ; Belotto-Silva, Cristina ^{[1, 2]} ; Hounie, Ana Gabriela ^{[1, 2]} ; Borcato, Sonia ^{[1, 2]} ; Moraes, Ivanil ^{[1, 2]} ; Joaquim, Marines Alves ^{[1, 2]} ; Cappi, Carolina ^{[1, 2]} ; Sampaio, Aline Santos ^{[1, 2]} ; de Mathis, Maria Alice ^{[1, 2]} ; Batistuzzo, Marcelo Camargo ^{[1, 2]} ; Lopes, Antonio Carlos ^{[1, 2]} ; Ferreira Rosa, Ana Carolina ^{[1, 2]} ; Muniz, Renan Kawano ^{[1, 2]} ; Marques, Andrea Horvath ^{[1, 2]} ; Santos, Luciana Cristina ^{[1, 2]} ; Taub, Anita ^{[1, 2]} ; de Souza Duran, Fabio Luis ^{[1, 2]} ; Dougherty, Darin Dean ^[4] ; Busatto, Geraldo Filho ^{[1, 2]} ; Bressan, Rodrigo Affonseca ^{[3, 5]} ; Miguel, Euripedes Constantino ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Dept Psychiat, Clin Hosp, Sch Med, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Psychiat, Clin Hosp, Sch Med, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Interdisciplinary Lab Clin Neurosci, Dept Psychiat, Sao Paulo - Brazil

^[4] Harvard Univ, Sch Med, Dept Psychiat, Massachusetts Gen Hosp, Boston, MA 02115 - USA

^[5] HIAE, IIEP, Sao Paulo - Brazil

• Document type: Journal article
• Source: Revista Brasileira de Psiquiatria; v. 31, n. 4, p. 345-353, DEC 2009.
• Web of Science Citations: 11

Abstract

OBJECTIVE: To describe a protocol that was based on an integrative neurobiological model of scientific investigation to better understand the pathophysiology of obsessive-compulsive disorder and to present the clinical and demographic characteristics of the sample. METHOD: A standardized research protocol that combines different methods of investigation (genetics, neuropsychology, morphometric magnetic resonance imaging and molecular neuroimaging of the dopamine transporter) obtained before and after treatment of drug-naïve adult obsessive-compulsive disorder patients submitted to a sequentially allocated 12-week clinical trial with a selective serotonin reuptake inhibitor (fluoxetine) and group cognitive-behavioral therapy. RESULTS: Fifty-two treatment-naïve obsessive-compulsive disorder patients entered the clinical trial (27 received fluoxetine and 25 received group cognitive-behavioral therapy). At baseline, 47 blood samples for genetic studies, 50 neuropsychological evaluations, 50 morphometrical magnetic resonance images and 48 TRODAT-1 single-photon emission computed tomography (SPECT) exams were obtained. After 12 weeks, 38 patients completed the protocol (fluoxetine = 20 and GCBT = 18). Thirty-eight neuropsychological evaluations, 31 morphometrical magnetic resonance images and 34 TRODAT-1 SPECT exams were obtained post-treatment. Forty-one healthy controls matched for age, gender, socioeconomic status, level of education and laterality were submitted to the same research procedures at baseline. CONCLUSION: The comprehensive treatment response protocol applied in this project allowing integration on genetic, neuropsychological, morphometrical and molecular imaging of the dopamine transporter data in drug-naïve patients has the potential to generate important original information on the neurobiology of obsessive-compulsive disorder, and at the same time be clinically meaningful. (AU)

• FAPESP's process: 06/50273-0 - Pharmacological augmentation strategies in treatment of resistant obsessive-compulsive disorder: a double-blind placebo-controlled trial
• Grantee: Juliana Belo Diniz
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)