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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

CLINICAL PROFILE OF CHILDREN WITH DOWN SYNDROME TREATED IN A GENETICS OUTPATIENT SERVICE IN THE SOUTHEAST OF BRAZIL

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Author(s):
Pavarino Bertelli, Erika Cristina [1] ; Biselli, Joice Matos [1] ; Bonfim, Daiana [1] ; Goloni-Bertollo, Eny Maria [1]
Total Authors: 4
Affiliation:
[1] FAMERP, Fac Med Sao Jose Rio Preto, UPGEM, Dept Biol Mol, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Revista da Associação Médica Brasileira; v. 55, n. 5, p. 547-552, SEP-OCT 2009.
Web of Science Citations: 5
Abstract

Considering that studies about the frequencies of phenotypic features of Down syndrome (DS) in the Brazilian population with large ethnic variability are scarce in literature, this study analyzed clinical and demographic characteristics of DS children from the Southeastern region of Brazil. Sixty-two DS children with free trisomy 21 were evaluated by physical examination using reference values that considered the children's gender and age at their presentation. Data about clinical complications were collected by retrospective analysis of the children's medical records and/or information supplied by their mothers. Statistical analysis was performed using Likelihood Ratio Test, with significance level less or equal to 5%. Clinical features observed in more than 90% of the individuals were flat facial profile, brachycephaly, slanted palpebral fissures, hypotonia at birth and flat nasal bridge. Congenital heart disease was present in 56.5% of the cases, verbal language acquisition disorder in 87%, and global delayed development in 77.8%. The comparison between our data and related literature showed a great variability of the phenotype features frequencies of DS among studies. Besides environmental factors, this can reflect individual as well as population characteristics. (AU)

FAPESP's process: 08/10932-0 - Genetic polymorphisms on folate metabolic pathway and susceptibility to chromosome 21 nondisjunction.
Grantee:Erika Cristina Pavarino
Support Opportunities: Regular Research Grants