The CALM and CALM/AF10 interactor CATS is a marker for proliferation

Author(s):Show less -

Archangelo, Leticia Froehlich ^{[1, 2, 3]} ; Greif, Philipp A. ^{[1, 2]} ; Hoelzel, Michael ^[4] ; Harasim, Thomas ^[4] ; Kremmer, Elisabeth ^[5] ; Przemeck, Gerhard K. H. ^[6] ; Eick, Dirk ^[5] ; Deshpande, Aniruddha Jayant ^{[1, 2]} ; Buske, Christian ^{[1, 2]} ; de Angelis, Martin Hrabe ^[6] ; Olalla Saad, Sara Teresinha ^[3] ; Bohlander, Stefan K. ^{[1, 2]}

Affiliation

^[1] Univ Munich, Hosp Grosshadern, Dept Med 3, D-81377 Munich - Germany

^[2] German Res Ctr Environm Hlth, Clin Cooperat Grp Leukemia, D-81377 Munich - Germany

^[3] Univ Estadual Campinas, UNICAMP, Hematol & Hemotherapy Ctr, BR-13083970 Campinas, SP - Brazil

^[4] German Res Ctr Environm Hlth, Inst Clin Mol Biol & Tumor Genet, D-81377 Munich - Germany

^[5] German Res Ctr Environm Hlth, Inst Mol Immunol, D-81377 Munich - Germany

^[6] German Res Ctr Environm Hlth, Inst Expt Genet, D-85764 Munich - Germany

• Document type: Journal article
• Source: MOLECULAR ONCOLOGY; v. 2, n. 4, p. 356-367, DEC 2008.
• Web of Science Citations: 11

Abstract

The CATS protein was recently identified as a novel CALM interacting protein. CATS increases the nuclear and specifically the nucleolar localization of the leukemogenic CALM/AF10 fusion protein. We cloned and characterized the murine Cats gene. Detailed analysis of murine Cats expression during mouse embryogenesis showed an association with rapidly proliferating tissues. interestingly, the Cats transcript is highly expressed in murine hematopoietic cells transformed by CALM/AF10. The CATS protein is highly expressed in leukemia, lymphoma and tumor cell lines but not in non-proliferating T-cells or human peripheral blood lymphocytes. CATS protein levels are cell cycle dependent and it is induced by mitogens, suggesting a role of CATS in the control of cell proliferation and possibly CALM/AF10-mediated leukemogenesis. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 07/08019-1 - Functional characterization of the CATS protein and its role in cellular proliferation and leukemogenesis
• Grantee: Leticia Fröhlich Archangelo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 07/54870-5 - Functional characterization of the protein and its role in cellular proliferation and leukemogenesis
• Grantee: Sara Teresinha Olalla Saad
• Support Opportunities: Regular Research Grants