Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Use of experimental design and effective mobility calculations to develop a method for the determination of antimicrobials by capillary electrophoresis

Full text
Author(s):
Vargas Mamani, Monica Cecilia [1] ; Amaya-Farfan, Jaime [2] ; Reyes Reyes, Felix Guillermo [3] ; Fracassi da Silva, Jose Alberto [1] ; Rath, Susanne [1]
Total Authors: 5
Affiliation:
[1] Univ Estadual Campinas, Inst Chem, Dept Analyt Chem, BR-13084971 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Dept Food & Nutr, BR-13083862 Campinas, SP - Brazil
[3] Univ Estadual Campinas, Dept Food Sci, BR-13083862 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Talanta; v. 76, n. 5, p. 1006-1014, SEP 15 2008.
Web of Science Citations: 20
Abstract

A capillary zone electrophoresis (CZE) method for the determination Of Chloramphenicol (CLP), danofloxacin (DANO), ciprofloxacin (CIPRO), enrofloxacin (ENRC), sulfamethazine (SMZ), sulfaquinoxaline (SQX) and sulfamethoxazole (SMX) is described. For the development. the effective mobilities were estimated and a central composite design was performed. The method was in-house validated for CLP. CIPRO, ENRO and SMX determination in pharmaceuticals. In comparison with the HPLC method recommended by the United States Pharmacopoeia, this CZE method exhibited the same performance, with the advantage that seven different antimicrobials in pharmaceutical formulations could be simultaneously determined. (C) 2008 Elsevier B.V. All rights reserved. (AU)