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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Transfer of antibodies across the placenta and in breast milk from mothers on intravenous immunoglobulin

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Author(s):
Palmeira, Patricia [1] ; Costa-Carvalho, Beatriz T. ; Arslanian, Christina [2] ; Pontes, Gerlandia N. [1, 2] ; Nagao, Aparecida T. [2, 3] ; Carneiro-Sampaio, Magda M. S. [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Fac Med, Dept Pediat, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Immunol, BR-05403000 Sao Paulo - Brazil
[3] Univ Fed Ceara, Dept Clin Anal & Toxicol, Fortaleza, Ceara - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PEDIATRIC ALLERGY AND IMMUNOLOGY; v. 20, n. 6, p. 528-535, SEP 2009.
Web of Science Citations: 34
Abstract

We studied the levels of immunoglobulins in colostrum, milk and sera from two common variable immunodeficiency (CVID) mothers (M1 and M2), and in sera from their newborn infants. During pregnancy they continued intravenous immunoglobulin therapy (IVIG). Antibody levels from maternal and cord blood collected at delivery and colostrum and milk, collected on the 3rd and 7th post-partum days, respectively, were analyzed. Although cord/maternal blood ratios of total immunoglobulins and subclasses, as well as specific antibodies differed between M1 and M2, both showed good placental transfer of anti-protein and anti-polysaccharide antibodies, despite lower cord/maternal blood ratios in M2. Anti-Streptococcus pneumoniae antibody avidity indexes were similar between paired maternal and cord serum. Both mothers' colostrum and milk samples showed only traces of IgA, and IgM and IgG levels in colostrum were within normal range in M1, whereas M2 presented elevated IgG and low IgM levels, when compared with healthy mothers. The study of colostrum and milk activity showed that they strongly inhibited enteropathogenic Escherichia coli adhesion in vitro. CVID patients must be informed about the relevance of regular IVIG administration during pregnancy, not only for their own health but also for their immune immature offspring. Breast-feeding should be encouraged as colostra from these CVID patients strongly inhibited E. coli adhesion to human epithelial cells thus providing immunological protection plus nutritional and psychological benefits for the infant. (AU)

FAPESP's process: 02/05880-4 - Primary immunodeficiences in high risk pediatric patients: relationships between clinical manifestations and genetic alterations
Grantee:Magda Maria Sales Carneiro-Sampaio
Support Opportunities: Research Projects - Thematic Grants