Properties of nanoparticles prepared from NdFeB-based compound for magnetic hyperthermia application

Author(s)

Perigo, E. A. ^[1] ; Silva, S. C. ^[2] ; de Sousa, E. M. B. ^[3] ; Freitas, A. A. ^[3] ; Cohen, R. ^[4] ; Nagamine, L. C. C. M. ^[4] ; Takiishi, H. ^[2] ; Landgraf, F. J. G. ^{[1, 5]}

Affiliation

^[1] Inst Technol Res, Ctr Proc & Prod Technol, BR-05508901 Sao Paulo - Brazil

^[2] Nucl & Energy Res Inst, Ctr Mat Sci & Technol, BR-05508000 Sao Paulo - Brazil

^[3] Ctr Dev Nucl Technol, Nanotechnol Serv, BR-31270970 Belo Horizonte, MG - Brazil

^[4] Univ Sao Paulo, Inst Phys, BR-05315970 Sao Paulo - Brazil

^[5] Univ Sao Paulo, Polytech Sch, BR-05508030 Sao Paulo - Brazil

• Document type: Journal article
• Source: Nanotechnology; v. 23, n. 17 MAY 4 2012.
• Web of Science Citations: 10

Abstract

Nanoparticles were prepared from a NdFeB-based alloy using the hydrogen decrepitation process together with high-energy ball milling and tested as heating agent for magnetic hyperthermia. In the milling time range evaluated (up to 10 h), the magnetic moment per mass at H = 1.59 MA m(-1) is superior than 70 A m(2) kg(-1); however, the intrinsic coercivity might be inferior than 20 kA m(-1). The material presents both ferromagnetic and superparamagnetic particles constituted by a mixture of phases due to the incomplete disproportionation reaction of Nd2Fe14BHx during milling. Solutions prepared with deionized water and magnetic particles exposed to an AC magnetic field (H-max similar to 3.7 kA m(-1) and f = 228 kHz) exhibited 26 K <= Delta T-max <= 44 K with a maximum estimated specific absorption rate (SAR) of 225 W kg(-1). For the pure magnetic material milled for the longest period of time (10 h), the SAR was estimated as similar to 2500 W kg(-1). In vitro tests indicated that the powders have acceptable cytotoxicity over a wide range of concentration (0.1-100 mu g ml(-1)) due to the coating applied during milling. (AU)

• FAPESP's process: 10/08018-8 - Reprocessing of commercial REFeB (RE = Nd or Pr) sintered magnets for preparation of bonded magnets and semi-hard magnetic compounds using hydrogen
• Grantee: Élio Alberto Périgo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral