Cadinane sesquiterpenoids of Phomopsis cassiae, an endophytic fungus associated with Cassia spectabilis (Leguminosae)

Author(s):Show less -

Silva, Geraldo Humberto ; Teles, Helder Lopes ; Zanardi, Lisinéia Maria ; Young, Maria Claudia Marx ; Eberlin, Marcos Nogueira ; Hadad, Renato ; Pfenning, Ludwig H. ; Costa-Neto, Claudio Miguel ; Castro-Gamboa, Ian ; Bolzani, Vanderlan da Silva ^[10] ; Araújo, Ângela Regina

• Document type: Journal article
• Source: Phytochemistry; v. 67, n. 17, p. 1964-1969, Sept. 2006.
• Field of knowledge: Physical Sciences and Mathematics - Chemistry

Abstract

Five cadinane sesquiterpenes derivatives were isolated by bioassay-guided fractionation from Phomopis cassiae, an endophytic fungus isolated from Cassia spectabilis. The structures of the two diastereoisomeric 3,9,12-trihydroxycalamenenes (1, 2); 3,12-dihydroxycalamenene (3); 3,12-dihydroxycadalene (4) and 3,11,12-trihydroxycadalene (5) were established on the basis of analyses of 1D and 2D NMR and HRTOFMS experiments. Antifungal activity of the isolates was evaluated against Cladosporium sphaerospermum and Cladosporium cladosporioides, revealing 5 as the most active compound. (AU)

• FAPESP's process: 03/02176-7 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II
• Grantee: Vanderlan da Silva Bolzani
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants