Cardiometabolic benefits of exercise training in an experimental model of metabolic syndrome and menopause

Author(s)

Sanches, Iris Callado ; Brito, Janaina de Oliveira ; Candido, Georgia Orsi ^[1] ; Dias, Danielle da Silva ; Jorge, Luciana ^[1] ; Irigoyen, Maria-Claudia ^[1] ; De Angelis, Katia ^[2]

Affiliation

^[1] Univ Sao Paulo, Inst Heart, Hypertens Unit, Sao Paulo - Brazil

^[2] Nove de Julho Univ, Sci Rehabil Program, Lab Translat Physiol, BR-05001100 Sao Paulo - Brazil

• Document type: Journal article
• Source: MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY; v. 19, n. 5, p. 562-568, MAY 2012.
• Web of Science Citations: 19

Abstract

Objective: The aim of this study was to investigate the cardiometabolic effects of exercise training in ovariectomized hypertensive rats both submitted and not submitted to fructose overload. Methods: Spontaneously hypertensive ovariectomized rats were divided into sedentary and trained (THO) groups submitted to normal chow and sedentary and trained groups submitted to fructose overload (100 g/L in drinking water for 19 wk). Exercise training was performed on a treadmill (8 wk). Arterial pressure (AP) was directly recorded. Cardiovascular autonomic control was evaluated through pharmacological blockade (atropine and propranolol) and in the time and frequency domains by spectral analysis. Results: The THO group presented reduced AP (approximately 16 mm Hg) and enhanced cardiac vagal tonus (approximately 49%) and baroreflex sensitivity (approximately 43%) compared with the sedentary hypertensive ovariectomized group. Exercise training attenuated metabolic impairment, resting tachycardia, cardiac and vascular sympathetic increases, and baroreflex sensitivity decrease induced by fructose overload in hypertensive rats. However, the trained hypertensive ovariectomized group submitted to fructose overload presented higher AP (approximately 32 mm Hg), associated with baroreflex sensitivity (approximately 69%) and parasympathetic dysfunctions compared with the THO group. Conclusions: These data suggest that the metabolic disorders in hypertensive rats after ovarian hormone deprivation could blunt and/or attenuate some exercise training benefits. (AU)

• FAPESP's process: 10/17188-4 - Dysfunction associated mechanisms to a menopause and syndrome metabolic experimental model: role of aerobic and resistance exercise training
• Grantee: Janaina de Oliveira Brito
• Support Opportunities: Scholarships in Brazil - Doctorate