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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Relationship Between Regional Brain Volumes and Cognitive Performance in the Healthy Aging: An MRI Study Using Voxel-Based Morphometry

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Author(s):
Squarzoni, Paula [1] ; Tamashiro-Duran, Jaqueline [1] ; Souza Duran, Fabio Luis [1] ; Santos, Luciana Cristina [1] ; Vallada, Homero Pinto [2] ; Menezes, Paulo Rossi [3] ; Scazufca, Marcia [2] ; Busatto Filho, Geraldo [1] ; Toledo de Ferraz Alves, Tania Correa [1, 4]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Dept Psychiat, Lab Psychiat Neuroimaging LIM 21, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Psychiat, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Prevent Med, Sao Paulo - Brazil
[4] ABC Reg Med Sch, Santo Andre - Brazil
Total Affiliations: 4
Document type: Journal article
Source: JOURNAL OF ALZHEIMER'S DISEASE; v. 31, n. 1, p. 45-58, 2012.
Web of Science Citations: 12
Abstract

The presence of cognitive impairment is a frequent complaint among elderly individuals in the general population. This study aimed to investigate the relationship between aging-related regional gray matter (rGM) volume changes and cognitive performance in healthy elderly adults. Morphometric magnetic resonance imaging (MRI) measures were acquired in a community-based sample of 170 cognitively-preserved subjects (66 to 75 years). This sample was drawn from the ``Sao Paulo Ageing and Health{''} study, an epidemiological study aimed at investigating the prevalence and risk factors for Alzheimer's disease in a low income region of the city of Sao Paulo. All subjects underwent cognitive testing using a cross-culturally battery validated by the Research Group on Dementia 10/66 as well as the SKT (applied on the day of MRI scanning). Blood genotyping was performed to determine the frequency of the three apolipoprotein E allele variants (APOE epsilon 2/epsilon 3/epsilon 4) in the sample. Voxelwise linear correlation analyses between rGM volumes and cognitive test scores were performed using voxel-based morphometry, including chronological age as covariate. There were significant direct correlations between worse overall cognitive performance and rGM reductions in the right orbitofrontal cortex and parahippocampal gyrus, and also between verbal fluency scores and bilateral parahippocampal gyral volume (p < 0.05, familywise-error corrected for multiple comparisons using small volume correction). When analyses were repeated adding the presence of the APOE epsilon 4 allele as confounding covariate or excluding a minority of APOE epsilon 2 carriers, all findings retained significance. These results indicate that rGM volumes are relevant biomarkers of cognitive deficits in healthy aging individuals, most notably involving temporolimbic regions and the orbitofrontal cortex. (AU)

FAPESP's process: 04/15336-5 - Brain abnormalities associated with cardiovascular risk factors: a population-based study using voxel-a-voxel morphometry by magnetic resonance and measures of glucose metabolism by positron-emission tomography
Grantee:Geraldo Busatto Filho
Support Opportunities: Regular Research Grants