Vitamin or mineral supplement intake and the risk of head and neck cancer: pooled analysis in the INHANCE consortium

Author(s):Show less -

Li, Qian ^[1] ; Chuang, Shu-Chun ^[2] ; Eluf-Neto, Jose ^[3] ; Menezes, Ana ^[4] ; Matos, Elena ^[5] ; Koifman, Sergio ^[6] ; Wuensch-Filho, Victor ^[3] ; Fernandez, Leticia ^[7] ; Daudt, Alexander W. ^[8] ; Curado, Maria Paula ^[9] ; Winn, Deborah M. ^[10] ; Franceschi, Silvia ^[11] ; Herrero, Rolando ^[11] ; Castellsague, Xavier ^[12] ; Morgenstern, Hal ^{[13, 14]} ; Zhang, Zuo-Feng ^[15] ; Lazarus, Philip ^[16] ; Muscat, Joshua ^[16] ; McClean, Michael ^[17] ; Kelsey, Karl T. ^[18] ; Hayes, Richard B. ^[19] ; Purdue, Mark P. ^[10] ; Schwartz, Stephen M. ^[20] ; Chen, Chu ^[20] ; Benhamou, Simone ; Olshan, Andrew F. ^[21] ; Yu, Guopei ^[22] ; Schantz, Stimson ^{[22, 23]} ; Ferro, Gilles ; Brennan, Paul ; Boffetta, Paolo ^{[9, 24]} ; Hashibe, Mia

Affiliation:Show less -

^[1] Chinese Acad Med Sci, Natl Off Canc Prevent & Control, Canc Inst Hosp, Beijing 100730 - Peoples R China

^[2] Imperial Coll London, London - England

^[3] Univ Sao Paulo, Sao Paulo - Brazil

^[4] Univ Fed Pelotas, Pelotas - Brazil

^[5] Univ Buenos Aires, Inst Oncol Angel H Roffo, RA-1053 Buenos Aires, DF - Argentina

^[6] Fundacao Oswaldo Cruz, Escola Nacl Saude Publ, Rio De Janeiro - Brazil

^[7] Inst Oncol & Radiobiol, Havana - Cuba

^[8] Hosp Clin Porto Alegre, Porto Alegre, RS - Brazil

^[9] Int Prevent Res Inst, Lyon - France

^[10] NCI, Bethesda, MD 20892 - USA

^[11] Int Agcy Res Canc, Prevent & Implementat Grp, F-69372 Lyon - France

^[12] CIBER ESP, ICO, IDIBELL, Lhospitalet De Llobregat - Spain

^[13] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 - USA

^[14] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 - USA

^[15] Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 - USA

^[16] Penn State Coll Med, Hershey, PA - USA

^[17] Boston Univ, Sch Publ Hlth, Boston, MA - USA

^[18] Brown Univ, Providence, RI 02912 - USA

^[19] NYU, Sch Med, New York, NY - USA

^[20] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 - USA

^[21] Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC - USA

^[22] New York Eye & Ear Infirm, New York, NY 10003 - USA

^[23] Natl Inst Hlth & Med Res, Paris - France

^[24] Mt Sinai Sch Med, New York, NY - USA

• Document type: Journal article
• Source: International Journal of Cancer; v. 131, n. 7, p. 1686-1699, OCT 1 2012.
• Web of Science Citations: 14

Abstract

To investigate the potential role of vitamin or mineral supplementation on the risk of head and neck cancer (HNC), we analyzed individual-level pooled data from 12 casecontrol studies (7,002 HNC cases and 8,383 controls) participating in the International Head and Neck Cancer Epidemiology consortium. There were a total of 2,028 oral cavity cancer, 2,465 pharyngeal cancer, 874 unspecified oral/pharynx cancer, 1,329 laryngeal cancer and 306 overlapping HNC cases. Odds ratios (OR) and 95% confidence intervals (CIs) for self reported ever use of any vitamins, multivitamins, vitamin A, vitamin C, vitamin E, and calcium, beta-carotene, iron, selenium and zinc supplements were assessed. We further examined frequency, duration and cumulative exposure of each vitamin or mineral when possible and stratified by smoking and drinking status. All ORs were adjusted for age, sex, race/ethnicity, study center, education level, pack-years of smoking, frequency of alcohol drinking and fruit/vegetable intake. A decreased risk of HNC was observed with ever use of vitamin C (OR = 0.76, 95% CI = 0.590.96) and with ever use of calcium supplement (OR = 0.64, 95% CI = 0.420.97). The inverse association with HNC risk was also observed for 10 or more years of vitamin C use (OR = 0.72, 95% CI = 0.540.97) and more than 365 tablets of cumulative calcium intake (OR = 0.36, 95% CI = 0.160.83), but linear trends were not observed for the frequency or duration of any supplement intake. We did not observe any strong associations between vitamin or mineral supplement intake and the risk of HNC. (AU)