Adenocarcinoma of the parotid salivary gland in a cow

Author(s)

Salgado, Breno S. ^{[1, 2, 3]} ; Monteiro, Lidianne N. ^{[1, 2]} ; Grandi, Fabrizio ^{[1, 2]} ; Nonogaki, Suely ^[4] ; Rocha, Rafael M. ^[4] ; Rocha, Noeme S. ^{[1, 2]}

Affiliation

^[1] Univ Estadual Paulista UNESP, Fac Med Botucatu, Dept Patol, Botucatu, SP - Brazil

^[2] Univ Estadual Paulista UNESP, Fac Med Vet & Zootecnia, Lab Patol Invest & Comparada, Dept Clin Vet, Botucatu, SP - Brazil

^[3] FEPI, Curso Med Vet, Itajuba - Brazil

^[4] Hosp AC Camargo Fund Antonio Prudente, Dept Anat Patol, Fundacao Antonio Prudente, Sao Paulo - Brazil

• Document type: Journal article
• Source: VETERINARY CLINICAL PATHOLOGY; v. 41, n. 3, p. 424-428, SEP 2012.
• Web of Science Citations: 1

Abstract

A 6-year-old Girolando dairy cow was presented for evaluation of a large subcutaneous facial mass. Fine-needle aspirates of the mass contained many neoplastic cells with high nuclear:cytoplasmic ratios arranged in sheets and loosely cohesive clusters with streaming erythrocytes and neutrophils in the background. Neoplastic cells were 1325 mu m in diameter and were round to cuboidal with variably distinct borders. Based on the signalment, anatomic location, and cytologic findings, differential diagnoses included salivary adenocarcinoma, squamous cell carcinoma, and mucoepidermoid carcinoma. The cow was euthanized and a necropsy was performed. The primary neoplasm arose from the left parotid salivary gland and meastatic tumor was found in the regional lymph nodes and lung. Histologically, the tumor was composed of anastomosing and irregular solid islets surrounded by scant stroma. Cells were negative for periodic acid-Schiff (PAS), PAS-diastase, and Alcian blue pH 2.5 stains, used to detect mucin. On immunohistochemical analysis, neoplastic luminal salivary gland cells expressed cytokeratin, but not S100, a-smooth muscle actin, or vimentin. Peripheral cells of neoplastic islets were immunoreactive for p63. The final diagnosis was nonsecretory adenocarcinoma of the parotid salivary gland. (AU)

• FAPESP's process: 10/51596-2 - S100A4 and osteopontin immunoexpression evaluation in canine spontaneous mammary carcinomas
• Grantee: Noeme Sousa Rocha
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/01610-1 - Evaluation of CD31, S100A4, and alpha SMA in the tumor microenvironment and their relation to endotelial-mesenchymal transition in canine spontaneous cutaneous melanomas
• Grantee: Noeme Sousa Rocha
• Support Opportunities: Regular Research Grants