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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Could a high-fat diet rich in unsaturated fatty acids impair the cardiovascular system?

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Author(s):
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Medei, Emiliano [1] ; Lima-Leopoldo, Ana Paula [2] ; Pereira-Junior, Pedro Paulo [1] ; Leopoldo, Andre Soares [3] ; Salome Campos, Dijon Henrique [3] ; Raimundo, Juliana Montani [4] ; Sudo, Roberto Takashi [4] ; Zapata-Sudo, Gisele [4] ; Bruder-Nascimento, Thiago [5] ; Cordellini, Sandra [5] ; Matheus Nascimento, Jose Hamilton [1] ; Cicogna, Antonio Carlos [3]
Total Authors: 12
Affiliation:
[1] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro - Brazil
[2] Univ Fed Espirito Santo, Dept Sports, Ctr Phys Educ & Sports, Vitoria - Brazil
[3] Sao Paulo State Univ Julio Mesquita Filho, Univ Estadual Paulista, Dept Clin & Cardiol, Sch Med, BR-18618000 Sao Paulo - Brazil
[4] Univ Fed Rio de Janeiro, Dept Farmacol Basica & Clin, Rio De Janeiro - Brazil
[5] Sao Paulo State Univ Julio Mesquita Filho, Univ Estadual Paulista, Inst Biosci, Dept Pharmacol, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: CANADIAN JOURNAL OF CARDIOLOGY; v. 26, n. 10, p. 542-548, DEC 2010.
Web of Science Citations: 9
Abstract

BACKGROUND: Dyslipidemia results from consumption of a diet rich in saturated fatty acids and is usually associated with cardiovascular disease. A diet rich in unsaturated fatty acids is usually associated with improved cardiovascular condition. OBJECTIVE: To investigate whether a high-fat diet rich in unsaturated fatty acids (U-HFD)-in which fatty acid represents approximately 45% of the total calories-impairs the cardiovascular system. METHODS: Male, 30-day-old Wistar rats were fed a standard (control) diet or a U-HFD containing 83% unsaturated fatty acid for 19 weeks. The in vivo electrocardiogram, the spectral analysis of heart rate variability, and the vascular reactivity responses to phenylephrine, acetylcholine, noradrenaline and prazosin in aortic ring preparations were analyzed to assess the cardiovascular parameters. RESULTS: After 19 weeks, the U-HFD rats had increased total body fat, baseline glucose levels and feed efficiency compared with control rats. However, the final body weight, systolic blood pressure, area under the curve for glucose, calorie intake and heart weight/final body weight ratio were similar between the groups. In addition, both groups demonstrated no alteration in the electrocardiogram or cardiac sympathetic parameters. There was no difference in the responses to acetylcholine or the maximal contractile response of the thoracic aorta to phenylephrine between groups, but the concentration necessary to produce 50% of maximal response showed a decrease in the sensitivity to phenylephrine in U-HFD rats. The cumulative concentration-effect curve for noradrenaline in the presence of prazosin was shifted similarly in both groups. CONCLUSIONS: The present work shows that U-HFD did not impair the cardiovascular parameters analyzed. (AU)

FAPESP's process: 09/03771-2 - Cardiovascular alterations in rats exposed or not to chronic stress during the obesity induction
Grantee:Thiago Bruder Do Nascimento
Support Opportunities: Scholarships in Brazil - Master