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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of Hepatitis B Virus (HBV) Genotype on the Clinical Course of Disease in Patients Coinfected with HBV and Hepatitis Delta Virus

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Author(s):
Kiesslich, Dagmar [1, 2] ; Crispim, Myuki Alfaia [2] ; Santos, Carlos [3] ; Ferreira, Fernando de Lima [1] ; Fraiji, Nelson Abrahim [1, 2] ; Komninakis, Shirley Vasconcelos [3] ; Diaz, Ricardo Sobhie [3]
Total Authors: 7
Affiliation:
[1] Univ Fed Amazonas, Viral Hepatitis Outpatient Ctr, Manaus, Amazonas - Brazil
[2] Univ Fed Amazonas, Amazonas Blood Ctr, Res Lab, Manaus, Amazonas - Brazil
[3] Univ Fed Sao Paulo, Retrovirol Lab, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Infectious Diseases; v. 199, n. 11, p. 1608-1611, JUN 1 2009.
Web of Science Citations: 28
Abstract

Objective. We evaluated the influence of hepatitis B virus (HBV) genotype on the course of disease in patients coinfected with HBV and hepatitis delta virus (HDV). Methods. We evaluated HBV genotypes in 190 patients, 140 of whom had chronic HBV monoinfection and 50 of whom had chronic HBV-HDV coinfection. Real-time polymerase chain reactions for the amplification of HBV DNA and HDV RNA were developed, and we compared the patient groups with respect to HBV genotype, viral load, alanine aminotransferase (ALT) and bilirubin levels, and disease severity. Results. Coinfected patients had higher ALT and bilirubin levels as well as a higher prevalence of liver cirrhosis and liver carcinoma. ALT levels were higher among individuals coinfected with HDV and HBV genotype F than among individuals infected only with HBV genotype F. Among HDV-HBV-coinfected patients, HDV load was lower among those infected with HBV genotype A than among those infected with HBV genotype D or genotype F. Conclusion. Liver inflammation and HDV load are influenced by HBV genotype in individuals coinfected with HBV and HDV. (AU)

FAPESP's process: 04/15856-9 - Prospective analysis of the virological and immunological characteristics in individuals with recent HIV-1 infection in the cities of São Paulo and Santos
Grantee:Ricardo Sobhie Diaz
Support Opportunities: Research Projects - Thematic Grants