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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biotransformation of Phenylacetonitrile to 2-Hydroxyphenylacetic Acid by Marine Fungi

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Author(s):
de Oliveira, Julieta Rangel [1] ; Mizuno, Carolina Megumi [2] ; Regali Seleghim, Mirna Helena [2] ; Diniz Javaroti, Darci Consolacao [2] ; Oliveira Rezende, Maria Olimpia [1] ; Landgraf, Maria Diva [1] ; Sette, Lara Duraes [3] ; Meleiro Porto, Andre Luiz [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Ecol & Biol Evolut, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Estadual Campinas, Div Recursos Microbianos, Ctr Pluridisciplinar Pesquisas Quim Biol & Agr, CPQBA, BR-13140000 Paulinia, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: MARINE BIOTECHNOLOGY; v. 15, n. 1, p. 97-103, FEB 2013.
Web of Science Citations: 13
Abstract

Marine fungi belonging to the genera Aspergillus, Penicillium, Cladosporium, and Bionectria catalyzed the biotransformation of phenylacetonitrile to 2-hydroxyphenylacetic acid. Eight marine fungi, selected and cultured with phenylacetonitrile in liquid mineral medium, catalyzed it quantitative biotransformation to 2-hydroxyphenylacetic acid. In this study, the nitrile group was firstly hydrolysed, and then, the aromatic ring was hydroxylated, producing 2-hydroxyphenylacetic acid with 51 % yield isolated. In addition, the 4-fluorophenylacetonitrile was exclusively biotransformed to 4-fluorophenylacetic acid by Aspergillus sydowii Ce19 (yield = 51 %). The enzymatic biotransformation of nitriles is not trivial, and here, we describe an efficient method for production of phenylacetic acids in mild conditions. (AU)