P63 expression in papillary cystadenoma and mucoepidermoid carcinoma of minor salivary glands

Author(s)

Fonseca, Felipe Paiva ^[1] ; Benevenuto de Andrade, Bruno Augusto ^[1] ; Lopes, Marcio Ajudarte ^[1] ; Rebelo Pontes, Helder Antonio ^[2] ; Vargas, Pablo Agustin ^[1] ; de Almeida, Oslei Paes ^[1]

Affiliation

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Piracicaba - Brazil

^[2] Fed Univ Para, Serv Oral Pathol, Joao de Barros Barreto Univ Hosp, BR-66059 Belem, Para - Brazil

• Document type: Journal article
• Source: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 115, n. 1, p. 79-86, JAN 2013.
• Web of Science Citations: 9

Abstract

Objective. The aim of this study was to investigate the expression of p63 protein in mucoepidermoid carcinoma and papillary cystadenoma of the salivary glands, and to evaluate the usefulness of this protein in distinguishing these tumors. Study Design. Immunoexpression of p63 protein was studied and quantified in 9 formalin-fixed paraffin-embedded mucous retention cysts, 4 papillary cystadenomas, and 19 low-grade and 9 high-grade mucoepidermoid carcinomas. Results. All cases were positive for p63 immunoexpression; however, it was observed that p63 labeling in mucous retention cysts and papillary cystadenomas was limited to the basal layers of the cystic spaces, whereas in low-grade mucoepidermoid carcinomas, positive nuclear staining was also found diffusely in the suprabasal layers. Mucoepidermoid carcinoma presented increased immunoexpression of p63 compared with the other groups. Conclusions. P63 immunohistochemical expression pattern can be helpful in distinguishing low-grade mucoepidermoid carcinoma from papillary cystadenoma of the salivary glands. (Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115:79-86) (AU)

• FAPESP's process: 09/53839-2 - Creation of a Digital Pathology Laboratory using a histological slidescanner
• Grantee: Oslei Paes de Almeida
• Support Opportunities: Multi-user Equipment Program