The I405V and Taq1B polymorphisms of the CETP gene differentially affect sub-clinical carotid atherosclerosis

Author(s):Show less -

Parra, Eliane Soler ^[1] ; Panzoldo, Natalia Baratella ^[1] ; Kaplan, Denise ^[1] ; Franco de Oliveira, Helena Coutinho ^[2] ; dos Santos, Jose Ernesto ^[3] ; Fernandes de Carvalho, Luiz Sergio ^[4] ; Sposito, Andrei Carvalho ^[4] ; Gidlund, Magnus ^[5] ; Nakamura, Ruy Tsutomu ^[6] ; de Souza Zago, Vanessa Helena ^[1] ; Nakandakare, Edna Regina ^[7] ; Rocha Quintao, Eder Carlos ^[7] ; de Faria, Eliana Cotta ^{[1, 8]}

Affiliation

^[1] Univ Estadual Campinas, Fac Med Sci, Lipids Lab, BR-13083877 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Inst Biol, Lipids Lab, BR-13083862 Campinas, SP - Brazil

^[3] Univ Sao Paulo, Fac Med, BR-14039900 Ribeirao Preto, SP - Brazil

^[4] Univ Estadual Campinas, Fac Med Sci, Div Cardiol, BR-13083887 Campinas, SP - Brazil

^[5] Univ Sao Paulo, Imunol Dept, BR-05508900 Sao Paulo - Brazil

^[6] Univ Estadual Campinas, Fac Med Sci, Dept Radiol, BR-13083887 Campinas, SP - Brazil

^[7] Univ Sao Paulo, Fac Med Sci, Lipids Lab LIM 10, BR-01246903 Sao Paulo - Brazil

^[8] Univ Estadual Campinas, FCM, Dept Patol Clin, BR-13084971 Barao Geraldo, SP - Brazil

• Document type: Journal article
• Source: LIPIDS IN HEALTH AND DISEASE; v. 11, OCT 5 2012.
• Web of Science Citations: 4

Abstract

Background: Cholesteryl ester transfer protein (CETP) plays a major role in lipid metabolism, but studies on the association of CETP polymorphisms with risks of cardiovascular disease are inconsistent. This study investigated whether the CETP gene I405V and Taq1B polymorphisms modified subclinical atherosclerosis in an asymptomatic Brazilian population sample. Methods: The polymorphisms were analyzed using polymerase chain reaction in 207 adult volunteers. Serum lipid profiles, oxLDL Ab titers, C-reactive protein and tumor necrosis factor-a concentrations and CETP and phospholipid transfer protein (PLTP) activities were determined, and common carotid artery intima-media thickness (cIMT) was measured using ultrasonography. Results: No differences in cIMT were observed between the presence or absence of the minor B2 and V alleles in either polymorphism. However, inverse correlations between mean cIMT and CETP activity in the presence of these polymorphisms were observed, and positive correlations of these polymorphisms with PLTP activity and oxLDL Ab titers were identified. Moreover, logistic multivariate analysis revealed that the presence of the B2 allele was associated with a 5.1-fold (CI 95%, OR: 1.26 - 21.06) increased risk for cIMT, which was equal and above the 66th percentile and positively interacted with age. However, no associations with the V allele or CETP and PLTP activities were observed. Conclusions: None of the studied parameters, including CETP activity, explained the different relationships between these polymorphisms and cIMT, suggesting that other non-determined factors were affected by the genotypes and related to carotid atherosclerotic disease. (AU)

• FAPESP's process: 06/60585-9 - Relation of the plasma HDL-cholesterol concentration with blood monocyte and whole body cholesterol metabolism parameters
• Grantee: Eder Carlos Rocha Quintão
• Support Opportunities: Research Projects - Thematic Grants