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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Caffeine reduces cadmium accumulation in the organism and enhances the levels of antioxidant protein expression in the epididymis

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Author(s):
Lacorte, Livia M. [1] ; Seiva, Fabio R. F. [2] ; Rinaldi, Jaqueline C. [1] ; Delella, Flavia K. [1] ; Moroz, Andrei [1] ; Sarobo, Carolina [1] ; Godinho, Antonio F. [3] ; Favaro, Wagner J. [4] ; Fernandes, Ana A. H. [2] ; Felisbino, Sergio L. [1]
Total Authors: 10
Affiliation:
[1] Univ Estadual Paulista, Dept Morphol, Inst Biosci, Botucatu, SP - Brazil
[2] Univ Estadual Paulista UNESP, Dept Chem & Biochem, Inst Biosci, BR-18618970 Botucatu, SP - Brazil
[3] Univ Estadual Paulista UNESP, CEATOX, Inst Biosci, BR-18618970 Botucatu, SP - Brazil
[4] Univ Campinas UNICAMP, Dept Struct & Funct Biol, Inst Biol, Campinas, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: REPRODUCTIVE TOXICOLOGY; v. 35, p. 137-143, JAN 2013.
Web of Science Citations: 19
Abstract

The aim of this study was to investigate the effects of caffeine (20 mg/L) intake on cadmium (15 mg/L) accumulation in the rat blood, testes, epididymis and prostate as well as cadmium-induced changes to the antioxidant defense system of the epididymis. Caffeine reduced the cadmium concentration in all tissues analyzed. Meanwhile, cadmium reduced catalase activity and increased superoxide dismutase (SOD) activity in the epididymis. Caffeine increased SOD activity, catalase and glutathione tissue expression and sustains the cadmium's effect on catalase and GSP-Px activity. No differences in the expression of metallothionein and lipid peroxidation were observed among the different treatments in the epididymis. In conclusion, low doses of cadmium alter the antioxidant enzymatic profile of the epididymis, but not induced oxidative lipid damage. Caffeine intake reduces overall cadmium accumulation in the organism and enhances the levels of antioxidant protein expression in the epididymis, thus exerting a protective effect against this metal. (C) 2012 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 09/52747-7 - Morphofuncitonal changes in Wistar rat prostate: fetal programming by protein restriction in utero and chronic exposure to cadmium and caffeine during puberty
Grantee:Sérgio Luis Felisbino
Support Opportunities: Regular Research Grants