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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Synthesis, characterization and antifungal activity of quaternary derivatives of chitosan on Aspergillus flavus

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Author(s):
Pedro, Rafael de Oliveira [1] ; Takaki, Mirelle [1] ; Castilho Goraye, Teresa Cristina [2] ; Del Bianchi, Vanildo Luiz [2] ; Thomeo, Joao Claudio [2] ; Tiera, Marcio Jose [1] ; de Oliveira Tiera, Vera Aparecida [1]
Total Authors: 7
Affiliation:
[1] Sao Paulo State Univ UNESP, Dept Chem & Environm Sci, Inst Biosci Humanities & Exact Sci IBILCE, Sao Paulo - Brazil
[2] Sao Paulo State Univ UNESP, Dept Technol & Food Engn, Inst Biosci Humanities & Exact Sci IBILCE, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: MICROBIOLOGICAL RESEARCH; v. 168, n. 1, p. 50-55, 2013.
Web of Science Citations: 33
Abstract

Two series of new chitosan derivatives were synthesized by reaction of deacetylated chitosan (CH) with propyl (CH-Propyl) and pentyl (CH-Pentyl) trimethylammonium bromides to obtain derivatives with increasing degrees of substitution (DS). The derivatives were characterized by H-1 NMR and potentiometric titration techniques and their antifungal activities on the mycelial growth of Aspergillus flavus were investigated in vitro. The antifungal activities increase with DS and the more substituted derivatives of both series, CH-Propyl and CH-Pentyl, exhibited antifungal activities respectively three and six times higher than those obtained with commercial and deacetylated chitosan. The minimum inhibitory concentrations (MIC) were evaluated at 24, 48 and 72 h by varying the polymer concentration from 0.5 to 16 g/L and the results showed that the quaternary derivatives inhibited the fungus growth at polymer concentrations four times lower than that obtained with deacetylated chitosan (CH). The chitosans modified with pentyltrimethylammonium bromide exhibited higher activity and results are discussed taking into account the degree of substitution (DS). (C) 2012 Elsevier GmbH. All rights reserved. (AU)

FAPESP's process: 12/03619-9 - Biofungicides: synteses and characterization anphiphilic derivatives of chitosan for application against Aspergillus genus species
Grantee:Vera Aparecida de Oliveira Tiera
Support Opportunities: Regular Research Grants