| Full text | |
| Author(s): |
Louzada Strufaldi, Maria Wany
[1]
;
Puccini, Rosana Fiorini
[1]
;
Amancio Silverio, Olga Maria
[1]
;
do Pinho Franco, Maria Carmo
[2]
Total Authors: 4
|
| Affiliation: | [1] Univ Fed Sao Paulo, Dept Pediat, Sch Med, BR-04023062 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Div Nephrol, Dept Physiol, Sch Med, BR-04023062 Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | EUROPEAN JOURNAL OF PEDIATRICS; v. 172, n. 1, p. 71-76, JAN 2013. |
| Web of Science Citations: | 2 |
| Abstract | |
Our aim was to investigate plasma levels of adiponectin, monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in low birth weight (LBW) children and to determine correlations among these adipokines and birth weight and cardiovascular disease risk factors. In a case-control study, the concentrations of adiponectin, MCP-1 and PAI-1 were measured in 180 schoolchildren (ages 6-11 years). MCP-1 and PAI-1 levels were significantly elevated in LBW children. Conversely, adiponectin concentration was significantly reduced in these children. Similar findings were observed after adjustment for current age, gender and abdominal circumference. Because the children with LBW had altered adipokine levels, as well as higher abdominal circumference, HOMA-IR and systolic blood pressure (SBP), we evaluated the correlation among these variables. These analyses showed that adiponectin levels were inversely correlated with systolic blood pressure (SBP) (r = -0.501; P < 0.001), HOMA-IR (r = -0.293; P = 0.023) and waist circumference (r = -0.317; P = 0.014). The proinflammatory markers were positively correlated with HOMA-IR (PAI-1: r = 0.358; P = 0.005) and waist circumference (PAI-1: r = 0.571; P < 0.001 and MCP-1: r = 0.267; P = 0.039). Conclusion: Adipokines levels were correlated with cardiovascular risk factors in LBW children, and these compounds could be involved in the mechanism that links birth weight to the development of cardiovascular diseases in adulthood. (AU) | |
| FAPESP's process: | 07/58044-2 - Birth weight and cardiovascular diseases: characterization of risk and genetic factors interrelation by identifying genomic imprinting mechanisms as well as genetic polymorphisms in homocysteine and eNOS pathways |
| Grantee: | Maria Do Carmo Pinho Franco |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 08/58963-0 - Birth weight, adipocytokines and factors associated with risk of cardiovascular diseases in children |
| Grantee: | Maria Wany Louzada Strufaldi |
| Support Opportunities: | Regular Research Grants |