Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Leptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile

Full text
Author(s):
Show less -
Moraes-Vieira, P. M. M. [1] ; Bassi, E. J. [1] ; Larocca, R. A. [2, 3, 4] ; Castoldi, A. [1] ; Burghos, M. [1] ; Lepique, A. P. [1] ; Quintana, F. J. [5] ; Araujo, R. C. [6] ; Basso, A. S. [7] ; Strom, T. B. [2, 3, 4] ; Camara, N. O. S. [8, 1]
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo - Brazil
[2] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 - USA
[3] Harvard Univ, Sch Med, Boston, MA - USA
[4] Transplant Inst, Boston, MA - USA
[5] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, Boston, MA 02115 - USA
[6] Univ Fed Sao Paulo, Dept Biophys, Sao Paulo - Brazil
[7] Univ Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo - Brazil
[8] Univ Fed Sao Paulo, Div Nephrol, Sao Paulo - Brazil
Total Affiliations: 8
Document type: Journal article
Source: AMERICAN JOURNAL OF TRANSPLANTATION; v. 13, n. 1, p. 36-44, JAN 2013.
Web of Science Citations: 24
Abstract

Leptin, an adipose-secreted hormone, links metabolism and immunity. Our aim was to determine whether leptin affects the alloimmune response. We used an allogeneic skin transplant model as a means to analyze the allograft immune response in Lepob/ob and wild-type mice. Leptin deficiency results in an increased frequency of Treg and Th2 cells and a prolonged graft survival. These effects of leptin deficiency indicate the importance of leptin and obesity in modulating the allograft immune responses. Our data suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection. (AU)

FAPESP's process: 07/07139-3 - The role of heme oxygenase 1 in different renal inflammatory process in experimental animal models
Grantee:Niels Olsen Saraiva Câmara
Support type: Research Projects - Thematic Grants
FAPESP's process: 12/02270-2 - New cellular, molecular and immunological mechanisms involved in acute and chronic renal injury: the search for new therapeutical approaches
Grantee:Niels Olsen Saraiva Câmara
Support type: Research Projects - Thematic Grants
FAPESP's process: 08/58564-9 - Study of adaptive immune response modulation by the sympathetic nervous system: emphasis on autoimmunity, Th17 cells and Foxp3 + regulatory T cells
Grantee:Alexandre Salgado Basso
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 09/50450-7 - Adipokines in experimental transplantation: interaction between leptin and the development of immunological tolerance
Grantee:Pedro Manoel Mendes de Moraes Vieira
Support type: Scholarships in Brazil - Doctorate