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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Walking promotes metabolic and baroreflex sensitivity improvement in fructose-fed male rats

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Author(s):
Machi, Jacqueline F. [1] ; Bernardes, Nathalia [2] ; Mostarda, Cristiano [1] ; Moraes-Silva, Ivana Cinthya [1] ; Irigoyen, Maria Claudia [1] ; De Angelis, Katia [2] ; Wichi, Rogerio B. [3]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sch Med, Heart Inst InCor, Hypertens Unit, BR-05403900 Sao Paulo - Brazil
[2] Nove Julho Univ, Translat Physiol Lab, Sao Paulo - Brazil
[3] Univ Fed Sergipe, Dept Phys Educ, Sergipe - Brazil
Total Affiliations: 3
Document type: Journal article
Source: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY; v. 113, n. 1, p. 41-49, JAN 2013.
Web of Science Citations: 9
Abstract

The aim of this study was to investigate metabolic and cardiovascular responses to walking in fructose-fed rats. Male Wistar rats were divided into control (C), sedentary fructose (SF) and walking fructose (WF). Fructose-fed rats received d-fructose (100 g/l). WF rats walked on a treadmill at constant load (0.3 km/h) during 1 h/day, 5 days/week for 8 weeks. Measurements of triglyceride concentrations, adipose tissue and glycemia were carried out together with insulin tolerance test to evaluate metabolic profile. Arterial pressure (AP) signals were directly recorded. Baroreflex sensitivity (BR) was evaluated by the reflex tachycardia (TR) and bradycardia (BR) to AP changes. The results showed that walking decreased the adipose tissue (SF: 6.5 +/- A 0.4; WF: 2.8 +/- A 0.1; C: 3.0 +/- A 0.3 g), blood triglyceride levels (SF: 291 +/- A 6.5; WF: 150 +/- A 8.1; C: 103 +/- A 4.5 mg/dl) and increased insulin sensitivity (SF: 2.5 +/- A 0.2; WF: 3.3 +/- A 0.32; C: 4.8 +/- A 0.4 %/min). Baroreflex sensitivity was improved in the WF group expressed by BR (SF: 0.75 +/- A 0.10; WF: 1.18 +/- A 0.10; C: 1.5 +/- A 0.14 ms/mmHg) and TR (SF: 0.80 +/- A 0.12; WF: 1.21 +/- A 0.10; C: 1.35 +/- A 0.11 ms/mmHg), as well as when verified by the alpha index. Although the WF group showed decreased AP when compared with the SF group, the values still enhanced in relation to C rats (SF: 137 +/- A 2; WF: 129 +/- A 1; C: 115 +/- A 6 mmHg). Our findings allow a better understanding of the effects of walking, a low-intensity exercise training, on the hemodynamic and metabolic aspects of male rats with metabolic syndrome and indicate that walking seems to be particularly effective in treating metabolic disturbances in this model. (AU)