| Full text | |
| Author(s): |
Adriana Maluf Elias Sallum
[1]
;
Maria Helena Bittencurt Kiss
[2]
;
Silvana Sachetti
[3]
;
Maria Bernadate Dutra Resende
[4]
;
Kelly Cristina Moutinho
[5]
;
Mary de Souza Carvalho
[6]
;
Clovis Arthur Almeida Silva
[7]
;
Suely Kazue Nagahashi Marie
[8]
Total Authors: 8
|
| Affiliation: | [1] USP. MS. Pediatric Department
[2] USP. MS. Children's Institute
[3] São Paulo Medical School. Santa Casa de Misericórdia. Pediatric Rheumatology Unit
[4] USP. MS. Department of Neurology
[5] University of São Paulo. Medical School. Laboratory of Neurological Investigation - Brasil
[6] University of São Paulo. Medical School. Clinical Hospital
[7] University of São Paulo. Medical School. Children's Institute
[8] University of São Paulo. Medical School. Department of Neurology
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | Arquivos de Neuro-Psiquiatria; v. 60, n. 4, p. 889-899, 2002-12-00. |
| Abstract | |
This study was based on a prospective and a retrospective analysis of 35 patients who met Bohan and Peter criteria for juvenile dermatomyositis diagnosis.The mean follow-up time was three years ten months. Calcinosis was present in five (14.28 %) patients, cutaneous ulcers in four (11.42%), and systemic involvement in nine (27.71%) patients. All patients presented alterations in the serum levels of muscle enzymes, and all of them were submitted to muscle biopsy as a diagnostic procedure. Nine (25.71%) patients received corticotherapy prior to and 26 (74.28%) after the muscle biopsy. Chloroquine, methotrexate, cyclosporine, cyclophosphamide and intravenous immunoglobulin were used in patients with poor response to corticotherapy. Continuation of cutaneous manifestations was observed in 4 (11.43%) patients, laboratorial activity in 1 (2.85%), cutaneous and laboratorial activities in 3 (8.57%). Ten (28.57%) patients were out of activity, and 17 (48.57%) in remission at study end-point, on March 2002. Two (5.71%) patients died. (AU) | |