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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Validation of a treatment algorithm for major depression in an older Brazilian sample

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Author(s):
Ribeiz, Salma R. I. [1] ; Avila, Renata [1] ; Martins, Camila B. [2] ; Moscoso, Marco A. A. [1] ; Steffens, David C. [3] ; Bottino, Cassio M. C. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Fac Med, Inst Psychiat, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Math & Stat, Sao Paulo - Brazil
[3] Univ Connecticut, Dept Psychiat, Sch Med, Farmington, CT 06107 - USA
Total Affiliations: 3
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY; v. 28, n. 6, p. 647-653, JUN 2013.
Web of Science Citations: 1
Abstract

Objective The aim of this study was to investigate the effectiveness of a modified version of the Duke Somatic Algorithm Treatment for Geriatric Depression (STAGED) in a Brazilian sample of older patients with major depression. Besides, we aimed to investigate possible baseline predictive factors for remission in this sample. Methods Sixty-seven depressed individuals were treated according to STAGED over 24 weeks in a prospective cohort design with follow-up. All patients had criteria for major depression and were at least 60 years of age at baseline enrollment. Results During this follow-up, 56 patients could be classified in remitted or not remitted group, 42.85% reached remission, and 57.14% did not reach remission. These results are even better than those found in the original study, probably due to the lower baseline depression severity of our sample. When baseline characteristics were compared between remitted and not remitted groups, scores of Mini Mental State Examination and Cambridge Cognitive Examination (CAMCOG) were the only variables with statistical significant difference (p<0.05) between groups. Logistic regression analysis was carried out to try to predict remission and statistical significance (p<0.05) was found only for baseline MMSE scores. It may mean that patients with mixed cognitive disorders and mood disorders have a worse course of depression. Conclusions This version of STAGED seems to be a useful strategy for treatment of depression in late life. Baseline general cognitive performance might be useful to predict remission of depression in older patients with mild to moderate depression. Further research with different population characteristics should be conducted in order to evaluate its usefulness and feasibility in different settings. Copyright (c) 2012 John Wiley \& Sons, Ltd. (AU)