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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Ageing is the main determinant of haemodynamics and autonomic cardiac changes observed in post-menopausal female rats

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Author(s):
Tezini, Geisa C. S. V. [1] ; Becari, Christiane [2] ; Zanotto, Camila Z. [2] ; Salgado, Maria Cristina O. [2] ; Tostes Passaglia, Rita de Cassia A. [2] ; Souza, Hugo C. D. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Dept Biomech Med & Rehabil, Sch Med Ribeirao Preto, Exercise Physiol Lab, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Dept Pharmacol, Sch Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL; v. 174, n. 1-2, p. 36-41, MAR 2013.
Web of Science Citations: 8
Abstract

The aim of this study was to evaluate and compare the effects of early and physiological menopause on cardiac autonomic parameters in aged female rats. To this end, female Wistar rats (22 and 82 weeks old, N =96) were divided into 4 groups: Young Sham-operated Rats, Aged Sham-operated Rats, Young Ovariectomised (OVX) Rats, and Aged OVX Rats. Young Sham-operated and OVX rats were used as controls. The cardiac autonomic parameters were investigated using different approaches: 1) pharmacological evaluation of the autonomic tonus with methylatropine and propranolol; 2) isolated cardiac contractility with 0-adrenergic agonists; and 3) quantification of the mRNA and protein level expression of cardiac beta-adrenergic receptors. Among the groups of aged female rats, both the Sham-operated and OVX rats showed higher basal mean arterial pressure and heart rate (FIR) values compared to their respective young counterparts. The aged groups also showed a predominance of the sympathetic autonomic component in the determination of HR, whereas the young rats showed a vagal predominance. An assessment of cardiac contractility showed that aged Sham-operated and OVX rats had lower contractile responses following the administration of dobutamine compared to their respective young counterparts. In addition, the aged groups showed higher mRNA and protein expression levels of the beta(1-)adrenergic receptors. In conclusion, our results show that haemodynamic alterations and impairment of the autonomic parameters were similar between the groups of rats subjected to early and physiological menopause. Moreover, these results seem to be due to the ageing process and not ovarian hormone deprivation. (C) 2012 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 08/10929-9 - Experimental study comparing the effects of early and physiological estrogen deficiency on cardiovascular control - the role of hormone replacement and aerobic physical training
Grantee:Hugo Celso Dutra de Souza
Support Opportunities: Regular Research Grants