Polymorphisms of estrogen receptor-alpha gene in Brazilian women with high breast density after menopause

Author(s)

Souza, Marilene Alicia ^[1] ; Fonseca, Angela Maggio ^[1] ; Bagnoli, Vicente R. ^[1] ; de Barros, Nestor ^[1] ; Franzolin, Solange O. B. ^[2] ; Carvalho, Katia C. ^[1] ; Soares-, Jr., Jose Maria ^[3] ; Baracat, Edmund C. ^[4]

Affiliation

^[1] Univ Sao Paulo, BR-17010250 Bauru - Brazil

^[2] Sao Paulo State Univ, Botucatu, SP - Brazil

^[3] Univ Fed Sao Paulo, Sao Paulo - Brazil

^[4] Hosp Clin Sao Paulo, Sao Paulo - Brazil

• Document type: Journal article
• Source: Gynecological Endocrinology; v. 29, n. 8, p. 771-774, AUG 2013.
• Web of Science Citations: 1

Abstract

The association of genetic polymorphism in the estrogen receptor alpha (ER alpha) gene and risk for diseases including breast cancer (BC) has been the subject of great interest. Objective: Checking on women with high breast density after menopause, the frequency of the Pvull and Xbal polymorphisms of the ER alpha gene and the correlation between them and the known risk factors for breast cancer. Method: Observational study with 308 women between 45 and 65 years old with high breast density, without hormonal therapy, menstruation for a year or more, breast and ovarian cancer history. It was characterized in clinical history and physical examination: menarche, menopause, parity, family history of BC, smoking, alcohol intake and body mass index. Results: The allelic and genotypic frequencies for ER alpha-Pvull and Xbal: p = 43.99%; p = 56.01%; pp = 32.14%; Pp = 47.73% and PP = 20.13%; X = 41.56%; x = 58.44%; xx = 33.44%; Xx = 50.00% and XX = 16.56%, respectively. The most frequent risk factors for BC: menarche before 12 years old (35.38%), nulliparity or first child after 28 years old (41.66%), family history of BC (19.16%) and overweight/obesity (62.01%). Conclusion: Allelic and genotypic distribution similar to literature. The risk factors for BC were more prevalent in women with high breast density but without significant associations with these polymorphisms. (AU)

• FAPESP's process: 09/54563-0 - The Obesity with and without metabolic syndrome as a risk factor for the Breast Cancer
• Grantee: Angela Maggio da Fonseca
• Support Opportunities: Regular Research Grants