Sagittal abdominal diameter as a marker for epicardial adipose tissue in premenopausal women

Author(s)

Junqueira Vasques, Ana Carolina ^[1] ; Matos Souza, Jose Roberto ^[1] ; Yamanaka, Ademar ^[1] ; de Oliveira, Maria da Saude ^[1] ; Novaes, Fernanda Satake ^[1] ; Pareja, Jose Carlos ^[1] ; Geloneze, Bruno ^[1]

Affiliation

^[1] Univ Estadual Campinas, Dept Internal Med, Sch Med, Lab Invest Metab & Diabet LIMED, Campinas, SP - Brazil

• Document type: Journal article
• Source: METABOLISM-CLINICAL AND EXPERIMENTAL; v. 62, n. 7, p. 1032-1036, JUL 2013.
• Web of Science Citations: 6

Abstract

Objective. Accumulation of epicardial (EAT) adipose tissue is associated with the development of an unfavorable metabolic risk profile. Gold standard methods used to assess this fat depot are not routinely applicable in the clinic. Anthropometric measures, including the sagittal abdominal diameter (SAD), have emerged as surrogate markers of visceral obesity. We determined the relationship between EAT measurement and cardiometabolic risk parameters and the potential use of the SAD, compared with other anthropometric parameters, as a practical estimation of EAT. Materials/Methods. Sixty-seven premenopausal women were evaluated. The anthropometric parameters that were measured included waist circumference, SAD, body mass index and waist-to-hip ratio. EAT was determined by echocardiogram. Visceral adipose tissue (VAT) was determined by abdominal ultrasound. Insulin sensitivity was assessed by the hyperglycemic clamp. Results. The accumulation of EAT was correlated with impaired insulin sensitivity and decreased adiponectin. All of the anthropometric measurements were correlated with EAT. Interestingly, EAT was most significantly correlated with the SAD. From the ROC analysis, we found that the SAD measurements were very accurate, presenting the highest area under the curve for EAT (0.81; p<0.01) when compared with the other measurements. In the multiple linear regression analysis, EAT was moderately predicted by the SAD (R-2=0.25; p<0.001). Conclusion. SAD, a simple anthropometric measure, accurately estimated EAT and thus represents a clinically useful non-invasive marker that can identify patients with EAT accumulation. (C) 2013 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 08/09451-7 - Insulin secretory capacity in healthy patients, in obese, in obese type 2 diabetes and in obese type 2 diabetes undergoing bariatric surgery through the hyperglycemic clamp.
• Grantee: Bruno Geloneze Neto
• Support Opportunities: Regular Research Grants
• FAPESP's process: 08/07312-0 - Insulin secretory capacity in healthy patients, in obese, in obese type 2 diabetes and in obese type 2 diabetes undergoing bariatric surgery through the hyperglycemic clamp
• Grantee: Ana Carolina Junqueira Vasques
• Support Opportunities: Scholarships in Brazil - Doctorate