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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Diffuse optical characterization of an exercising patient group with peripheral artery disease

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Author(s):
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Mesquita, Rickson C. [1, 2] ; Putt, Mary [3] ; Chandra, Malavika [1] ; Yu, Guoqiang [4] ; Xing, Xiaoman [1] ; Han, Sung Wan [3] ; Lech, Gwen [5] ; Shang, Yu [4] ; Durduran, Turgut [6] ; Zhou, Chao [7] ; Yodh, Arjun G. [1] ; Mohler, III, Emile R. [8]
Total Authors: 12
Affiliation:
[1] Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 - USA
[2] Univ Estadual Campinas, Inst Phys, BR-13083859 Campinas, SP - Brazil
[3] Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 - USA
[4] Univ Kentucky, Ctr Biomed Engn, Lexington, KY 40506 - USA
[5] Univ Penn, Sch Nursing, Philadelphia, PA 19104 - USA
[6] ICFO Inst Ciencies Foton, Barcelona 08860 - Spain
[7] Lehigh Univ, Dept Elect & Comp Engn, Bethlehem, PA 18015 - USA
[8] Mohler, Emile R., III, Univ Penn, Dept Med, Perelman Sch Med, Cardiovasc Div, Sect Vasc Med, Philadelphia, PA 19104 - USA
Total Affiliations: 8
Document type: Journal article
Source: Journal of Biomedical Optics; v. 18, n. 5 MAY 2013.
Web of Science Citations: 13
Abstract

Peripheral artery disease (PAD) is a common condition with high morbidity. While measurement of tissue oxygen saturation (StO2) has been demonstrated, this is the first study to assess both StO2 and relative blood flow (rBF) in the extremities of PAD patients. Diffuse optics is employed to measure hemodynamic response to treadmill and pedal exercises in 31 healthy controls and 26 patients. For StO2, mild and moderate/severe PAD groups show pronounced differences compared with controls. Pre-exercise mean StO2 is lower in PAD groups by 9.3% to 10.6% compared with means of 63.5% to 66.2% in controls. For pedal, relative rate of return of StO2 to baseline is more rapid in controls (p < 0.05). Patterns of rBF also differ among groups. After both exercises, rBF tend to occur at depressed levels among severe PAD patients compared with healthy (p < 0.05); post-treadmill, rBF tend to occur at elevated levels among healthy compared with severe PAD patients (p < 0.05). Additionally, relative rate of return to baseline StO2 is more rapid among subjects with reduced levels of depression in rBF (p = 0.041), even after adjustment for ankle brachial index. This suggests a physiologic connection between rBF and oxygenation that can be measured using diffuse optics, and potentially employed as an evaluative tool in further studies. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE) (AU)

FAPESP's process: 12/02500-8 - Instrumentation and methodology development for cerebral oxygenation, blood flow and metabolic monitoring with diffuse optical spectroscopies
Grantee:Rickson Coelho Mesquita
Support Opportunities: Research Grants - Young Investigators Grants