BRAF: A Tool in the Decision to Perform Elective Neck Dissection?

Author(s)

Dutenhefner, Simone E. ^[1] ; Marui, Suemi ^[2] ; Santos, Andre B. O. ^[1] ; de Lima, Erika Urbano ^[2] ; Inoue, Milton ^[1] ; Brandao Neto, Jose S. ^[1] ; Shiang, Christina ^[1] ; Fukushima, Julia T. ^[1] ; Cernea, Claudio R. ^[2] ; Friguglietti, Celso U. M. ^[3]

Affiliation

^[1] Inst Canc State Sao Paulo ICESP, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med, Lab Cellular & Mol Endocrinol LIM 25, Sao Paulo - Brazil

^[3] Ctr Study Thyroid Canc CECATIR, Sao Paulo - Brazil

• Document type: Journal article
• Source: THYROID; v. 23, n. 12, p. 1541-1546, DEC 1 2013.
• Web of Science Citations: 14

Abstract

Background: Some studies have demonstrated a correlation between the presence of a BRAF mutation and aggressive characteristics, including lymph node metastasis in papillary thyroid carcinoma (PTC). Prophylactic central neck dissection (CND) has been proposed for treatment of PTC. Given the potential complications of CND, we undertook a prospective study to determine the correlation between the BRAF mutation and lymph node metastasis. Methods: A total of 51 patients with PTC underwent total thyroidectomy and routine prophylactic CND. All patients were tested for the BRAF mutation. Results: Positive lymph nodes were found in 54.9% of patients. The BRAF mutation was found in 15 patients (29%). BRAF was not correlated with lymph node metastases. Lymph node metastases were correlated with multifocality (p=0.005) and angiolymphatic invasion (p=0.003) in univariate analysis. Age was also significant in multivariate analysis. Conclusions: Testing for the BRAF mutation does not help in deciding whether or not to perform CND. (AU)

• FAPESP's process: 09/07544-0 - Analysis of V600E BRAF mutation in fine needle aspiration from thyroid nodule with suspicious or papillary carcinoma diagnosis
• Grantee: Suemi Marui
• Support Opportunities: Regular Research Grants