| Full text | |
| Author(s): |
Mendes-Junior, C. T.
[1]
;
Castelli, E. C.
[2]
;
Meyer, D.
[3]
;
Simoes, A. L.
[4]
;
Donadi, E. A.
[5]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto - Brazil
[2] Univ Estadual Paulista, Dept Patol, Fac Med Botucatu, Botucatu, SP - Brazil
[3] Univ Sao Paulo, Dept Genet & Biol Evolut, Inst Biociencias, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Genet, Fac Med Ribeirao Preto, BR-14040901 Ribeirao Preto - Brazil
[5] Univ Sao Paulo, Div Imunol Clin, Dept Clin Med, Fac Med Ribeirao Preto, BR-14040901 Ribeirao Preto - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Genes and Immunity; v. 14, n. 8, p. 518-526, DEC 2013. |
| Web of Science Citations: | 10 |
| Abstract | |
HLA-G has an important role in the modulation of the maternal immune system during pregnancy, and evidence that balancing selection acts in the promoter and 3'UTR regions has been previously reported. To determine whether selection acts on the HLA-G coding region in the Amazon Rainforest, exons 2, 3 and 4 were analyzed in a sample of 142 Amerindians from nine villages of five isolated tribes that inhabit the Central Amazon. Six previously described single-nucleotide polymorphisms (SNPs) were identified and the Expectation-Maximization (EM) and PHASE algorithms were used to computationally reconstruct SNP haplotypes (HLA-G alleles). A new HLA-G allele, which originated in Amerindian populations by a crossing-over event between two widespread HLA-G alleles, was identified in 18 individuals. Neutrality tests evidenced that natural selection has a complex part in the HLA-G coding region. Although balancing selection is the type of selection that shapes variability at a local level (Native American populations), we have also shown that purifying selection may occur on a worldwide scale. Moreover, the balancing selection does not seem to act on the coding region as strongly as it acts on the flanking regulatory regions, and such coding signature may actually reflect a hitchhiking effect. (AU) | |
| FAPESP's process: | 13/19382-0 - Genetic diversity of the HLA-G coding region in Amerindian populations from the Brazilian Amazon: a possible role of natural selection |
| Grantee: | Celso Teixeira Mendes Junior |
| Support Opportunities: | Regular Research Grants - Publications - Scientific article |