| Full text | |
| Author(s): |
de Carvalho, Samara Camacari
[1]
;
Apolinario, Leticia Montanholi
[1]
;
Michelin Matheus, Selma Maria
[2]
;
Santo Neto, Humberto
[1]
;
Marques, Maria Julia
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Estadual Campinas UNICAMP, Inst Biol, Dept Biol Estrutural & Func, BR-13083970 Campinas, SP - Brazil
[2] Univ Estadual Paulista, Inst Biociencias, Dept Anat, BR-18618000 Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Journal of Neuroimmunology; v. 264, n. 1-2, p. 41-47, NOV 15 2013. |
| Web of Science Citations: | 20 |
| Abstract | |
In dystrophic mdx mice and in Duchenne muscular dystrophy, inflammation contributes to myonecrosis. Previously, we demonstrated that eicosapentaenoic acid (EPA) decreased inflammation and necrosis in dystrophic muscle. In the present study, we examined the effects of EPA and the corticoid deflazacort (DFZ) as modulators of M1 (iNOS-expressing cells) and M2 (CD206-expressing cells) macrophages. Mdx mice (14 days old) received EPA or DFZ for 16 days. The diaphragm, biceps brachii and quadriceps muscles were studied. Immunofluorescence, immunoblotting and ELISA assays showed that EPA increased interleucin-10, reduced interferon-y and was more effective than DFZ in promoting a shift from M1 to M2. (C) 2013 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 10/13412-7 - Population of macrophages in skeletal muscles of mdx mice treated with eicosapentaenoic acid |
| Grantee: | Samara Camaçarí de Carvalho |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 12/15492-3 - Pharmacological therapy of the dystrophinopathies: fibrosis and muscular regeneration in mdx mice treated with omega-3 |
| Grantee: | Samara Camaçarí de Carvalho |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 10/14750-3 - Eicosapentaenoic acid x deflazacort: mechanisms of action and effects in the dystrophic mdx mice |
| Grantee: | Letícia Montanholi Apolinário |
| Support Opportunities: | Scholarships in Brazil - Master |