Lipid-based nanocarriers (SLN/NLC and remote-loading liposomes) used to improve th...
| Full text | |
| Author(s): |
de Araujo, Daniele R.
[1]
;
da Silva, Deyse C.
[1]
;
Barbosa, Raquel M.
[2]
;
Franz-Montan, Michelle
[2]
;
Cereda, Cintia M. S.
[2]
;
Padula, Cristina
[3]
;
Santi, Patrizia
[3]
;
de Paula, Eneida
[2]
Total Authors: 8
|
| Affiliation: | [1] ABC Fed Univ, Nat & Human Sci Ctr, BR-09210580 Santo Andre - Brazil
[2] Univ Estadual Campinas, Inst Biol, Dept Biochem, BR-13083862 Campinas, SP - Brazil
[3] Univ Parma, I-43100 Parma - Italy
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | Expert Opinion on Drug Delivery; v. 10, n. 11, p. 1551-1563, NOV 2013. |
| Web of Science Citations: | 31 |
| Abstract | |
Introduction: Dermal and transdermal drug delivery systems offer the possibility to control the release of the drug for an extended period of time. In particular, skin-delivery of local anesthetics (LA) is one of the most important strategies to increase the local drug concentration and to reduce systemic adverse reactions. Areas covered: During the development phase of new formulations for skin-delivery of LA one should consider a set of desirable features such providing suitable adhesion, easy application/removal and also to be biocompatible, biodegradable and non-toxic. This review emphasizes the main strategies for skin-delivery of LA considering those features in relation to the composition of the delivery systems described. The topics highlight the relationships between physico-chemical studies and pharmaceutical applications for liposomes and solid lipid nanoparticles as well as the formulation and clinical applications for hydrogels and patches. Expert opinion: The development of LA skin-delivery systems using hydrogels and different permeation enhancers, liposomes or lipid nanoparticles (as isolated carrier systems or as their dispersion in a gel-base) and patches have been explored as alternatives to commercial formulations, modifying the release rate of LA, increasing bioadhesive properties and reducing toxicity, resulting in an improved therapeutic efficacy. This review should provide to the reader a special emphasis on four delivery-systems, comprising the group of liposomes and lipid nanoparticles, hydrogels and patches technologies looking forward their application for skin anesthesia. (AU) | |
| FAPESP's process: | 10/11475-1 - Development and pharmacological evaluation of drug-delivery systems containing tramadol in thermoreversible hydrogels for pain treatment |
| Grantee: | Daniele Ribeiro de Araujo |
| Support type: | Regular Research Grants |
| FAPESP's process: | 06/00121-9 - New formulations for the controlled release of local anesthetics in dentistry: from development to clinical tests |
| Grantee: | Eneida de Paula |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 11/05581-6 - Thermoreversible polymeric hydrogels and liposomal systems for transdermal delivery of lidocaine |
| Grantee: | Deyse Cardoso da Silva |
| Support type: | Scholarships in Brazil - Master |