A silver complex with ibuprofen: Synthesis, solid state characterization, DFT calculations and antibacterial assays

Author(s)

Pereira e Silva, Irlene Maria ^[1] ; Profirio, Daniel de Moraes ^[1] ; Ferraz de Paiva, Raphael Enoque ^[2] ; Lancellotti, Marcelo ^[3] ; Barboza Formiga, Andre Luiz ^[1] ; Corbi, Pedro Paulo ^[2]

Affiliation

^[1] Univ Estadual Campinas, Inst Chem, Coordinat Chem Lab, BR-13083970 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Bioinorgan & Med Chem Res Lab, BR-13083970 Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Inst Biol, Biotechnol Lab, BR-13083970 Campinas, SP - Brazil

• Document type: Journal article
• Source: Journal of Molecular Structure; v. 1049, p. 1-6, OCT 8 2013.
• Web of Science Citations: 20

Abstract

The present work describes the synthesis of a silver(I) complex with the non-steroidal anti-inflammatory ibuprofen, Ag-ibu. Elemental and thermal analyses indicate a 1:1 metal/ligand composition. Thermogravimetric analysis shows that Ag-ibu decomposition starts at 180 degrees C, and ends at 400 degrees C (mass loss 64.6%; calcd. 65.5%). UV/Vis kinetic measurements suggest the decomposition of Ag-ibu in dimethyl sulfoxide, with the appearance of a broad band in the spectrum of the complex in the range 300-500 nm. Infrared and solid state C-13 NMR spectra show the coordination of ibuprofen to silver through the carboxylate group. The DFT calculations led us to. propose a dimeric silver bridging structure for the complex. Biological studies show the antibacterial activity of the Ag-ibu complex against Gram-positive and Gram-negative bacterial strains, with MIC values ranging from 6.25 to 12.5 mu g mL(-1). (c) 2013 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 12/08230-2 - Synthesis, characterization and pharmacological studies of Ag(I), Au(I), Pt(II) and Pd(II) complexes with bioactive ligands
• Grantee: Pedro Paulo Corbi
• Support Opportunities: Regular Research Grants