Electrochemical sensor for ranitidine determination based on carbon paste electrode modified with oxovanadium (IV) salen complex

Author(s)

Raymundo-Pereira, Paulo A. ^{[1, 2]} ; Teixeira, Marcos F. S. ^[1] ; Fatibello-Filho, Orlando ^[3] ; Dockal, Edward R. ^[3] ; Bonifacio, Viviane Gomes ^[4] ; Marco Lino-Junior, Luiz H. ^[4]

Affiliation

^[1] Univ Estadual Paulista, Fac Ciencias & Tecnol, Dept Fis Quim & Biol, Presidente Prudente, SP - Brazil

^[2] Univ Sao Paulo, Inst Quim, BR-13566590 Sao Paulo - Brazil

^[3] Univ Fed Sao Carlos, Cent Ciencias Exatas & Tecnol, Dept Quim, BR-13560 Sao Carlos, SP - Brazil

^[4] Univ Fed Parana, Dept Quim, BR-81531990 Curitiba, PR - Brazil

• Document type: Journal article
• Source: Materials Science & Engineering C-Materials for Biological Applications; v. 33, n. 7, p. 4081-4085, OCT 1 2013.
• Web of Science Citations: 13

Abstract

The preparation and electrochemical characterization of a carbon paste electrode modified with the N, N-ethylene-bis(salicyllideneiminato)oxovanadium (IV) complex ({[}VO(salen)]) as well as its application for ranitidine determination are described. The electrochemical behavior of the modified electrode for the electroreduction of ranitidine was investigated using cyclic voltammetry, and analytical curves were obtained for ranitidine using linear sweep voltammetry (LSV) under optimized conditions. The best voltammetric response was obtained for an electrode composition of 20% (m/m) {[}VO(salen)] in the paste, 0.10 mol L-1 of KCl solution (pH 5.5 adjusted with HCl) as supporting electrolyte and scan rate of 25 mV s(-1), A sensitive linear voltammetric response for ranitidine was obtained in the concentration range from 9.9 x 10(-5) to 1.0 x 10(-3) mol L-1, with a detection limit of 6.6 x 10(-5) mol L-1 using linear sweep voltammetry. These results demonstrated the viability of this modified electrode as a sensor for determination, quality control and routine analysis of ranitidine in pharmaceutical formulations. (C) 2013 Published by Elsevier B.V. (AU)

• FAPESP's process: 08/07298-7 - Study of polymeric films of thiophene-Schiff base complexes in the construction of electrochemical sensors
• Grantee: Paulo Augusto Raymundo Pereira
• Support Opportunities: Scholarships in Brazil - Master