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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neurotoxic action of permethrin in Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae) female ticks. Morphological and cytochemical evaluation of the central nervous system

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Author(s):
Roma, Gislaine Cristina [1] ; Camargo-Mathias, Maria Izabel [1] ; de Oliveira, Patricia Rosa [1] ; Scopinho Furquim, Karim Christina [1] ; Bechara, Gervasio Henrique [1]
Total Authors: 5
Affiliation:
[1] Univ Estadual Paulista, UNESP, BR-13506900 Rio Claro, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Veterinary Parasitology; v. 196, n. 3-4, p. 482-491, SEP 23 2013.
Web of Science Citations: 12
Abstract

Studies on the molecular bases of the neurotoxic action of acaricides are found in the literature; but there are no studies of this action on the nervous system of ticks at the cellular level. The present study describes the morphological and cytochemical changes in the synganglion of Rhipicephalus sanguineus semi-engorged females exposed to different concentrations of permethrin, a pyrethroid with recognized neurotoxic action. Permethrin induced the degeneration of the synganglion through a process of apoptosis involving autophagy, characterized by the condensation and margination of the chromatin, formation of blebs in the nuclear envelope and fragmentation of the nucleus, loss of shape of neural cells and integrity of cellular membrane, cytoplasmic shrinkage, and lower levels of acid phosphatase in the nervous tissue as the concentration of permethrin increased. This study provided further evidence of the neurotoxic action of permethrin, which impairs the metabolism of R. sanguineus nervous systems, and consequently the physiology of other systems, dependent on the neural control. These results provide cytochemical and histological confirmation of the neurotoxic action of permethrin, previously inferred from molecular and tick behavioral evidence. (c) 2013 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 11/06865-8 - Morphophysiology comparative study of the nervous system of larvae, nymphs and adults of Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae) and cell evaluation of synganglia from semi-engorged females exposed to permethrin and to andiroba oil
Grantee:Gislaine Cristina Roma
Support type: Scholarships in Brazil - Young Researchers