Polymorphisms in schizophrenia candidate gene UFD1L may contribute to cognitive deficits

Author(s):Show less -

Ota, Vanessa K. ^{[1, 2]} ; Berberian, Arthur A. ^{[1, 3]} ; Gadelha, Ary ^{[1, 3]} ; Santoro, Marcos L. ^{[1, 2]} ; Ottoni, Gustavo L. ^[4] ; Matsuzaka, Camila T. ^[3] ; Mari, Jair J. ^[3] ; Melaragno, Maria I. ^[2] ; Lara, Diogo R. ^[4] ; Smith, Marilia A. C. ^[2] ; Belangero, Sintia I. ^{[1, 3, 2]} ; Bressan, Rodrigo A. ^{[1, 3]}

Affiliation

^[1] Univ Fed Sao Paulo UNIFESP, Dept Psiquiatria, LiNC, BR-04023900 Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Dept Morfol & Genet, Disciplina Genet, BR-04023900 Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Dept Psiquiatria, BR-04023900 Sao Paulo - Brazil

^[4] Pontificia Univ Rio Grande Sul PUCRS, Fac Biociencias, Porto Alegre, RS - Brazil

• Document type: Journal article
• Source: PSYCHIATRY RESEARCH; v. 209, n. 1, p. 110-113, AUG 30 2013.
• Web of Science Citations: 7

Abstract

We aimed to investigate UFD1L polymorphisms in schizophrenia and in relation to cognition. A total of 299 cases and 363 controls were genotyped, and 130 patients completed nine neuropsychological tests. We found that rs5992403 AA-genotype carriers showed lower scores on the set-shifting task. Therefore, UFD1L may participate in the core cognitive deficits observed in schizophrenia. (C) 2013 Elsevier Ireland Ltd. All rights reserved. (AU)

• FAPESP's process: 11/50740-5 - Prevention in schizophrenia and bipolar disorder from neuroscience to the community: a multiphase, multimodal and translational platform for research and intervention
• Grantee: Rodrigo Affonseca Bressan
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 07/58736-1 - Investigation of 22q11.2 chromosomal region in the pathogenesis of cardiac alterations and schizophrenia
• Grantee: Marilia de Arruda Cardoso Smith
• Support Opportunities: Regular Research Grants