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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Panic Disorder and Agoraphobia in OCD patients: Clinical profile and possible treatment implications

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Author(s):
Torres, Albina R. [1] ; Ferrao, Ygor. A. [2] ; Shavitt, Roseli G. [3] ; Diniz, Juliana B. [3] ; Costa, Daniel L. C. [3] ; do Rosario, Maria Conceicao [4] ; Miguel, Euripedes C. [3] ; Fontenelle, Leonardo F. [5]
Total Authors: 8
Affiliation:
[1] Univ Estadual Paulista, Botucatu Med Sch, Dept Neurol Psychol & Psychiat, Sao Paulo - Brazil
[2] Hlth Sci Fed Univ Porto Alegre, Dept Psychiat, Porto Alegre, RS - Brazil
[3] Univ Sao Paulo, Sch Med, Dept Psychiat, BR-05508 Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Sao Paulo - Brazil
[5] Univ Fed Rio de Janeiro, Inst Psychiat, Anxiety & Depress Res Program, BR-21941 Rio De Janeiro - Brazil
Total Affiliations: 5
Document type: Journal article
Source: COMPREHENSIVE PSYCHIATRY; v. 55, n. 3, p. 588-597, APR 2014.
Web of Science Citations: 7
Abstract

Objective: Panic Disorder (PD) and agoraphobia (AG) are frequently comorbid with obsessive compulsive disorder (OCD), but the correlates of these comorbidities in OCD are fairly unknown. The study aims were to: 1) estimate the prevalence of PD with or without AG (PD), AG without panic (AG) and PD and/or AG (PD/AG) in a large clinical sample of OCD patients and 2) compare the characteristics of individuals with and without these comorbid conditions. Method: A cross-sectional study with 1001 patients of the Brazilian Research Consortium on Obsessive Compulsive Spectrum Disorders using several assessment instruments, including the Dimensional Yale Brown Obsessive Compulsive Scale and the Structured Clinical Interview for DSM-IV-TR Axis I Disorders. Bivariate analyses were followed by logistic regression models. Results: The lifetime prevalence of PD was 15.3% (N = 153), of AG 4.9% (N = 49), and of PD/AG 20.2% (N = 202). After logistic regression, hypochondriasis and specific phobia were common correlates of the three study groups. PD comorbidity was also associated with higher levels of anxiety, having children, major depression, bipolar I, generalized anxiety and posttraumatic stress disorders. Other independent correlates of AG were: dysthymia, bipolar 11 disorder, social phobia, impulsive compulsive internet use, bulimia nervosa and binge eating disorder. Patients with PD/AG were also more likely to be married and to present high anxiety, separation anxiety disorder, major depression, impulsive compulsive internet use, generalized anxiety, posttraumatic stress and binge eating disorders. Conclusions: Some distinct correlates were obtained for PD and AG in OCD patients, indicating the need for more specific and tailored treatment strategies for individuals with each of these clinical profiles. (C) 2014 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 05/55628-8 - Phenotypic, genetic, immunological and neurobiological characterization of the obsessive compulsive disorder and its implications for treatment
Grantee:Eurípedes Constantino Miguel Filho
Support Opportunities: Research Projects - Thematic Grants