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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Short-Term Evaluation of Grafts Fixed With Either N-Butyl-2-Cyanocrylate or Screws

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Author(s):
Salata, Luiz A. [1] ; Mariguela, Viviane C. [1] ; Antunes, Antonio A. [1] ; Grossi-Oliveira, Gustavo [1] ; Almeida, Adriana [1] ; Taba, Jr., Mario [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Fac Dent, Dept Oral & Maxillofacial Surg & Periodont, BR-14040904 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY; v. 72, n. 4, p. 676-682, APR 2014.
Web of Science Citations: 7
Abstract

Purpose: N-butyl-2-cyanoacrylate (NB-Cn) is an alternative method for onlay graft fixation and might be efficient for preserving the graft volume. Our aim was to analyze the gene expression and mineralized tissue variations of calvarial bone grafting fixed in the mandible with either NB-Cn or a titanium screw (TiS). Materials and Methods: New Zealand rabbits had bilateral calvarial grafts fixed at both sides of the mandible with either NB-Cn or a TiS. The rabbits were sacrificed at 4 and 8 days, and micro-computed tomography analysis was performed. For molecular analysis, the gene expression of interleukin-6, interleukin-10, and tumor necrosis factor-alpha was assessed. Quantification using real-time polymerase chain reaction was performed. Statistical analysis was performed using the paired Student t test (P < .05). Results: Bone graft fixation with NB-Cn promoted superior volume and density preservation. The percentage of mineralized tissue at the center portion and border of the graft was very similar (NB-Cn, 50.6% +/- 8.3% and 50.3% +/- 10.6%, respectively) and superior than in the TiS group (32.5% +/- 3.5% and 33.8% +/- 6%, respectively). Genes from the NB-Cn group were upregulated compared with those in the TiS group at the initial phases of bone healing (4 days), with the profile reversed at the 8-day point. At day 8, the osteoclastogenesis-related genes were upregulated in the TiS group. Conclusions: Onlay bone grafts fixed with screws induced more inflammation during the initial remodeling process than did NB-Cn. The differences in the incorporation into the host bed suggest that the use of adhesives for graft fixation will promote superior volume and density preservation. (C) 2014 American Association of Oral and Maxillofacial Surgeons (AU)

FAPESP's process: 11/19479-9 - Onlay bone grafts fixation and integration with N-butil-2-cyanoacrilate, positional screws and lag screws: a histological, micro-CT and biomolecular study in rabbits
Grantee:Luiz Antonio Salata
Support Opportunities: Regular Research Grants