Temporal lobe epilepsy in children: Executive and mnestic impairments

Author(s)

Rzezak, Patricia ^{[1, 2]} ; Valente, Kette D. ^{[2, 3]} ; Duchowny, Michael S. ^{[4, 5, 6]}

Affiliation

^[1] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med, Dept & Inst Psychiat, Lab Psychiat Neuroimaging LIM 21, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Psychiat, Fac Med, Clin Neurophysiol Lab, Sao Paulo - Brazil

^[4] Miami Childrens Hosp, Inst Brain, Miami, FL - USA

^[5] Miami Childrens Hosp, Dept Neurol, Miami, FL - USA

^[6] Florida Int Univ, Dept Neurol, Wertheim Coll Med, Miami, FL 33199 - USA

• Document type: Review article
• Source: Epilepsy & Behavior; v. 31, p. 117-122, FEB 2014.
• Web of Science Citations: 16

Abstract

The current definition of epilepsy emphasizes the importance of cognitive impairment for a complete understanding of the disorder. Cognitive deficits have distinct functional manifestations that differentially impact the daily life experiences of children and adolescents with epilepsy and are a particular concern as they frequently impair academic performance. In particular, memory impairment and executive dysfunction are common disabilities in adults with temporal lobe epilepsy but are less easily recognized and studied in the pediatric population. This review focuses on the consequences of early-onset temporal lobe epilepsy for the development of memory and executive function and discusses current theories to explain these deficits. (C) 2013 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 13/11361-4 - Association study of polymorphisms in serotoninergic pathway and temporal lobe epilepsy caused by hippocampal sclerosis
• Grantee: Kette Dualibi Ramos Valente
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/09025-3 - Executive and memory functions of patients with mesial temporal sclerosis: association between neuropsychological evaluation and new neuroimage techniques
• Grantee: Geraldo Busatto Filho
• Support Opportunities: Regular Research Grants