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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Whey Protein Hydrolysate Enhances HSP90 but Does Not Alter HSP60 and HSP25 in Skeletal Muscle of Rats

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Author(s):
Moura, Carolina Soares [1] ; Barboza Lollo, Pablo Christiano [1] ; Morato, Priscila Neder [1] ; Nisishima, Luciana Hisayama [1] ; Carneiro, Everardo Magalhaes [2] ; Amaya-Farfan, Jaime [1]
Total Authors: 6
Affiliation:
[1] Univ Campinas UNICAMP, Fac Food Engn, Dept Food & Nutr, Sao Paulo - Brazil
[2] Univ Campinas UNICAMP, Inst Biol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PLoS One; v. 9, n. 1 JAN 20 2014.
Web of Science Citations: 11
Abstract

Whey protein hydrolysate (WPH) intake has shown to increase HSP70 expression. The aim of the present study was to investigate whether WPH intake would also influences HSP90, HSP60 and HSP25 expression, as well as associated parameters. Forty-eight male Wistar rats were divided into sedentary (unstressed) and exercised (stressed) groups, and were fed with three different sources of protein: whey protein (WP), whey protein hydrolysate (WPH) and casein (CAS) as a control, based on the AIN93G diet for 3 weeks. WPH intake increased HSP90 expression in both sedentary and exercised animals compared to WP or CAS, however no alteration was found from exercise or diet to HSP60 or HSP25. Co-chaperone Aha1 and p-HSF1 were also increased in the exercised animals fed with WPH in comparison with WP or CAS, consistent with enhanced HSP90 expression. VEGF and p-AKT were increased in the WPH exercised group. No alteration was found in BCKDH, PI3-Kinase (p85), GFAT, OGT or PGC for diet or exercise. The antioxidant system GPx, catalase and SOD showed different responses to diet and exercise. The data indicate that WPH intake enhanced factors related to cell survival, such as HSP90 and VEGF, but does not alter HSP60 or HSP25 in rat skeletal muscle. (AU)

FAPESP's process: 11/13035-1 - The effect of consumption of milk protein serums on HSP biomarkers and biochemical parameters in rats
Grantee:Jaime Amaya Farfan
Support Opportunities: Regular Research Grants