| Full text | |
| Author(s): |
Gouveia, Nancy Lima
[1]
;
Camargo, Michelle
[1]
;
Caseiro, Marcos Montani
[2]
;
Ramos Janini, Luiz Mario
[1]
;
Araripe Sucupira, Maria Cecilia
[1]
;
Diaz, Ricardo Sobhie
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Fed Sao Paulo, Paulista Sch Med, Sao Paulo - Brazil
[2] Ctr Univ Lusiada, Santos, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | VIRUS GENES; v. 48, n. 3, p. 421-428, JUN 2014. |
| Web of Science Citations: | 1 |
| Abstract | |
HIV has extraordinary genetic mutability, both among individuals and at the population level. However, studies of primary HIV-1 infection and serum-converters indicate that the viral population is homogeneous at the sequence level, which suggests clonal HIV transmission. It remains unclear whether this feature applies to the female population. Ten single genome amplification sequences were generated from ten individuals (five females) with recent heterosexually acquired HIV infection as determined by the serologic testing algorithm for recent HIV seroconversion. Intra-individual genetic diversity was equally low in both genders (< 2 %), with mean and median variations of 0.8 and 0 %, respectively. All of the subjects were infected with clade B. Three subjects (two females) appeared to be infected by two related viral populations, and four subjects harbored non-R5 strains. Our results support the hypothesis of clonal selection for sexual transmission of HIV-1 in both genders. Future studies that generate a larger number of clones, preferably by next generation deep sequencing, are needed to confirm these results. (AU) | |
| FAPESP's process: | 98/14381-4 - Determination of genotypic resistance and genetic diversity in cases of recent infection by the Human Immunodeficiency Virus (HIV-1) |
| Grantee: | Ricardo Sobhie Diaz |
| Support Opportunities: | Research Projects - Thematic Grants |