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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis

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Author(s):
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Chapla, Vanessa Mara [1] ; Zeraik, Maria Luiza [1] ; Ximenes, Valdecir F. [2] ; Zanardi, Lisineia Maria [1] ; Lopes, Marcia N. [1] ; Cavalheiro, Alberto Jose [1] ; Silva, Dulce Helena S. [1] ; Young, Maria Claudia M. [3] ; da Fonseca, Luiz Marcos [4] ; Bolzani, Vanderlan S. [1] ; Araujo, Angela Regina [1]
Total Authors: 11
Affiliation:
[1] Univ Estadual Paulista, UNESP, NuBBE Nucleo Bioensaios Biossintese & Ecofisiol, Inst Quim Organ, Inst Quim, BR-14800900 Araraquara, SP - Brazil
[2] Univ Estadual Paulista, UNESP, Dept Quim, Fac Ciencias, BR-17033360 Bauru, SP - Brazil
[3] Nucleo Pesquisa Fisiol & Bioquim, Inst Bot, BR-04301902 Sao Paulo - Brazil
[4] Univ Estadual Paulista, UNESP, Fac Ciencias Farmaceut Araraquara, Dept Anal Clin, BR-14801902 Araraquara, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Molecules; v. 19, n. 5, p. 6597-6608, MAY 2014.
Web of Science Citations: 18
Abstract

Chemical investigation of an acetonitrile fraction from the endophytic fungus Phomopsis sp. led to the isolation of the new natural product 2-hydroxy-alternariol (7) together with the known compounds cytochalasins J (1) and H (2), 5'-epialtenuene (3) and the mycotoxins alternariol monomethyl ether (AME, 4), alternariol (AOH, 5) and cytosporone C (6). The structure of the new compound was elucidated by using 1-D and 2-D NMR (nuclear magnetic resonance) and high resolution mass spectrometry. The cytochalasins J (1) and H (2) and AOH (5) exhibited potent inhibition of the total ROS (reactive oxygen species) produced by stimulated human neutrophils and acted as potent potential anti-inflammatory agents. Moreover, cytochalasin H (2) demonstrated antifungal and acetylcholinesterase enzyme (AChE) inhibition in vitro. (AU)

FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC