The Endocannabinoid System and the Neuroendocrine Control of Hydromineral Balance

Author(s)

Ruginsk, S. G. ^[1] ; Vechiato, F. M. V. ^[1] ; Elias, L. L. K. ^[1] ; Antunes-Rodrigues, J. ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Fisiol, BR-14049 Ribeirao Preto, SP - Brazil

• Document type: Review article
• Source: Journal of Neuroendocrinology; v. 26, n. 6, p. 370-376, JUN 2014.
• Web of Science Citations: 2

Abstract

Endocannabinoids (ECBs) are ubiquitous lipophilic agents, and this characteristic is consistent with the wide range of homeostatic functions attributed to the ECB system. There is an increasing number of studies showing that the ECB system affects neurotransmission within the hypothalamic neurohypophyseal system. We provide an overview of the primary roles of ECBs in the modulation of neuroendocrine function and, specifically, in the control of hydromineral homeostasis. Accordingly, the general aspects of ECB-mediated signalling, as well as the specific contributions of the central component of the ECB system to the integration of behavioural and endocrine responses that control body fluid homeostasis, are discussed. (AU)

• FAPESP's process: 10/02748-4 - Water and sodium appetite following water deprivation: modulation by the endocannabinoid system.
• Grantee: Silvia Graciela Ruginsk Leitão
• Support Opportunities: Scholarships in Brazil - Post-Doctoral