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Neuroendocrine control of hydromineral balance in obese rats

Grant number: 16/20132-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2016
Effective date (End): October 31, 2017
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:José Antunes Rodrigues
Grantee:Gabriel de Andrade Ishioka
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/09799-1 - Energy balance and body fluid homeostasis control: from cells to the physiological systems, AP.TEM

Abstract

Obesity is a well-studied phenomenon concerning its nutritional, metabolic, and cardiovascular aspects. This is due to its elevated prevalence around the world. It is generally associated with a variety of comorbidities such as cardiovascular diseases, diabetes, hypertension, and dyslipidemia. However, little is known about how the systems that regulate hydroelectrolytic homeostasis are acting in an obese individual. This work has the objective to clarify how obesity modulates the hydromineral balance. For this purpose, Wistar male rats treated with a high-fat diet (60% lipids) during 15 weeks will be submitted to a 24-h fluid deprivation. Functional, hormonal, and gene expression parameters will be determined in these animals in order to observe the effect of adiposity on the fluid homeostasis.