| Full text | |
| Author(s): |
Sergio Podgaec
[1]
;
João Antonio Dias Junior
[2]
;
Charles Chapron
[3]
;
Ricardo Manoel de Oliveira
[4]
;
Edmund Chada Baracat
[5]
;
Maurício Simões Abrão
[6]
Total Authors: 6
|
| Affiliation: | [1] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas
[2] Universidade de São Paulo. Faculdade de Medicina
[3] Université Descartes Paris V. CHU Cochin- Sant Vincent de Paul. Department de Gynécologie - França
[4] RDO Diagnósticos
[5] Universidade de São Paulo. Faculdade de Medicina
[6] Universidade de São Paulo. Faculdade de Medicina. Departamento de Obstetrícia e Ginecologia
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | Revista da Associação Médica Brasileira; v. 56, n. 1, p. 92-98, 2010-00-00. |
| Abstract | |
OBJECTIVE: This study analyzed the relationship between clinical characteristics of endometriosis and Th1/Th2 immune response patterns. METHODS: A prospective study was performed with 65 patients with endometriosis (Group A) and 33 without the disease (Group B). Measurement of IL 2, 4 and 10, TNF-alpha and IFN-gamma was carried out in peripheral blood and peritoneal fluid. RESULTS: Serum TNF-alpha was higher in patients with endometriosis who had deep dyspareunia compared to controls (mean 4.5 pg/ml and 2.3 pg/ml, p<0.05). Among these patients (n=32), 65.5% had deep endometriosis. Patients with endometriosis and infertility had higher IL-2 concentrations in peritoneal fluid than controls (mean 5.9 pg/ml and 0.2 pg/ml, p<0.05). Among these patients (n=22), 63.5% (n=14) had deep endometriosis. A higher concentration of IL-10 was also observed in patients with ovarian endometriosis when compared to those without this type of disease, as well as when compared to control group patients (mean 50pg/ml, 18.7pg/ml and 25.7pg/ml, p<0.05). CONCLUSIONS: These results suggest that when specific clinical data are associated with a higher production of certain cytokines, there is a Th1 response pattern that may be related to deep infiltrating endometriosis. (AU) | |
| FAPESP's process: | 05/01218-3 - Immunological response evaluation in patients with Endometriosis |
| Grantee: | Maurício Simões Abrão |
| Support Opportunities: | Regular Research Grants |