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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Natural Products from Cyanobacteria with Antimicrobial and Antitumor Activity

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Author(s):
Silva-Stenico, Maria Estela [1] ; Kaneno, Ramon [2] ; Zambuzi, Fabiana Albani [3] ; Vaz, Marcelo G. M. V. [4] ; Alvarenga, Danillo O. [5] ; Fiore, Marli Fatima [6]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo. Ctr Nucl Energy Agr
[2] Sao Paulo State Univ. Dept Microbiol & Immunol
[3] Sao Paulo State Univ. Dept Microbiol & Immunol
[4] Univ Sao Paulo. Ctr Nucl Energy Agr
[5] Univ Sao Paulo. Ctr Nucl Energy Agr
[6] Univ Sao Paulo. Ctr Nucl Energy Agr
Total Affiliations: 6
Document type: Journal article
Source: CURRENT PHARMACEUTICAL BIOTECHNOLOGY; v. 14, n. 9, p. 820-828, OCT 2013.
Web of Science Citations: 10
Abstract

Cyanobacteria are an important source of structurally bioactive metabolites, with cytotoxic, antiviral, anticancer, antimitotic, antimicrobial, specific enzyme inhibition and immunosuppressive activities. This study focused on the antitumor and antimicrobial activities of intra and extracellular cyanobacterial extracts. A total of 411 cyanobacterial strains were screened for antimicrobial activity using a subset of pathogenic bacteria as target. The in vitro antitumor assays were performed with extracts of 24 strains tested against two murine cancer cell lines (colon carcinoma CT-26 and lung cancer 3LL). Intracellular extracts inhibited 49 and 35% of Gram-negative and Gram-positive pathogenic bacterial growth, respectively. Furthermore, the methanolic intracellular extract of Cylindrospermopsis raciborskii CYP011K and Nostoc sp. CENA69 showed inhibitory activity against the cancer cell lines. The extracellular extract from Fischerella sp. CENA213 and M. aeruginosa NPJB-1 exhibited inhibitory activity against 3LL lung cancer cells at 0.8 mu g ml(-1) and Oxynema sp. CENA135, Cyanobium sp. CENA154, M. aeruginosa NPJB-1 and M. aeruginosa NPLJ-4 presented inhibitory activity against CT26 colon cancer cells at 0.8 mu g ml(-1). Other extracts were able to inhibit 3LL cell-growth at higher concentrations (20 mu g ml(-1)) such as Nostoc sp. CENA67, Cyanobium sp. CENA154 and M. aeruginosa NPLJ-4, while CT26 cells were inhibited at the same concentration by Nostoc sp. CENA67 and Fischerella sp. CENA213. These extracts presented very low inhibitory activity on human peripheral blood lymphocytes. The results showed that some cyanobacterial strains are a rich source of natural products with potential for pharmacological and biotechnological applications. (AU)

FAPESP's process: 09/05474-5 - Bioprospection of cyanobacteria: screening cyanopeptides for pharmaceutical and biotechnological applications
Grantee:Maria Estela Stenico
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 10/18732-0 - Bioactive natural products from marine cyanobacteria
Grantee:Marcelo Gomes Marçal Vieira Vaz
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 11/20307-8 - Effect of low concentrations of antineoplastic agents on peripheral human blood lymphocytes
Grantee:Fabiana Albani Zambuzi
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 11/08092-6 - Genome sequencing of the cyanobacterium Nostoc sp. CENA67 and anotation of secondary metabolism genes
Grantee:Danillo Oliveira de Alvarenga
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 10/09867-9 - Bioprospection of cyanobacteria: screening cyanopeptides for pharmaceutical and biotechnological applications
Grantee:Maria Estela Stenico
Support Opportunities: Scholarships in Brazil - Young Researchers