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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hantaviruses and cardiopulmonary syndrome in South America

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Moraes Figueiredo, Luiz Tadeu [1] ; de Souza, William Marciel [1] ; Ferres, Marcela [2] ; Alcira Enria, Delia [3]
Total Authors: 4
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Virol Res Ctr, BR-14049 Ribeirao Preto, Si - Brazil
[2] Pontificia Univ Catolica Chile, Escuela Med, Ctr Invest Med, Div Pediat, Lab Infectol & Virol Mol, Santiago - Chile
[3] Inst Nacl Enfermedades Virales Humanas, Pergamino, Buenos Aires - Argentina
Total Affiliations: 3
Document type: Journal article
Source: VIRUS RESEARCH; v. 187, p. 43-54, JUL 17 2014.
Web of Science Citations: 37

Hantavirus (Bunyaviridae) cardiopulmonary syndrome (HCPS) is an emerging health problem in South America due to urban growth and to the expansion of agriculture and cattle-raising areas into ecosystems containing most of the species of Sigmodontinae rodents that act as hantavirus reservoirs. About 4000 HCPS cases have been reported in South America up to 2013, associated with the following hantaviruses: Andes, Anajatuba, Araraquara (ARQV), Paranoa, Bermejo, Castelo dos Sonhos, Juquitiba, Araucaria, Laguna Negra, Lechiguanas, Maripa, Oran, Rio Mamore and Tunari. The transmission of hantavirus to man occurs by contact with or through aerosols of excreta and secretions of infected rodents. Person-to-person transmission of hantavirus has also been reported in Argentina and Chile. HCPS courses with a capillary leaking syndrome produced by the hantavirus infecting lung endothelial cells and mostly with a severe inflammatory process associated with a cytokine storm. HCPS starts as a dengue-like acute febrile illness but after about 3 days progresses to respiratory failure and cardiogenic shock, leading to a high fatality rate that reaches 50% for patients infected with ARQV. (C) 2014 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 12/24150-9 - Research of virus in wild rodents, mosquitoes and ticks
Grantee:William Marciel de Souza
Support type: Scholarships in Brazil - Doctorate